联合检测tPA、PAI-1、uPA及uPAR对急性脑梗死诊治及预判的价值

目的对急性脑梗死病人进行血浆tPA、PAI-1、uPA及uPAR水平的联合检测,探讨其治疗观察及预后判定的临床价值。方法急性脑梗死病人(36例)及对照组在治疗前和治疗后分别进行血浆tPA、PAI-1、uPA及uPAR的联合检测(ELISA法)。结果 36例脑梗死病人治疗前与对照组相比tPA、PAI-1、uPA和uPAR水平均有明显增高(均P<0.01);治疗后与治疗前比较tPA又有明显升高(P<0.05),而PAI-1,uPA and uPAR则在治疗后明显降低(P<0.05,P<0.01),PAI-1及uPAR降至接近对照组水平(P>0.05)。结论血浆tPA、PAI-1、uPA和uPAR水平的变化与脑梗死病人的治疗状况密切相关,联合检测有利于对急性脑梗死的治疗观察和预后判定。

Value of Combining Detecting tPA, PAI-1,uPA and uPAR in the Patients with Acute Cerebral Infarction for Its Diagnostic, Treatment and Prognosis-assessment

Objective To study the clinical value of combining detecting the levels of tPA,PAI-1,uPA and uPAR in plasma of patients with acute cerebral infarction for treatment observation and progn-assessment.Methods PAI-1,uPA and uPAR were detected respectively by ELASA in 36 cases of the patients with acute cerebral infarction in pre-therapy,pro-treatment and control groups.Results Compared to the control group,the levels of tPA,PAI-1,uPA and uPAR of pre-therapy group were obviously high(all P<0.01).Compared to the pre-therapy group,the level of pro-treatment tPA was obviously high(P<0.05),the levels of PAI-1,uPA and uPAR were obviously low(P<0.05,P<0.01),and the levels of PAI-1 and uPAR were decreased to the levels of control group.Conclusion The plasma levels of tPA,PAI-1,uPA and uPAR are closely interrelated with the treatment state in the patients with acute cerebral infarction.Combining detecting the levels of tPA,PAI-1,uPA and uPAR is benifit for the evaluation of the progn-assessment and treatment state in the patients with acute cerebral infarction.