妊娠期高血压疾病患者凝血指标的变化及意义

目的 分析妊娠期高血压疾病患者与正常足月妊娠妇女凝血相关指标的改变与病情严重程度关系.方法 收集110例妊娠期高血压疾病患者（其中包括42例妊娠期高血压患者、27例轻度子痫前期患者、41例重度子痫前期患者）及50例正常晚期妊娠孕妇的血样及新生儿的出生体重.并行PLT、MPV、PT、TT、APTT、FIB、D-D、AT-Ⅲ测定.结果 ①妊娠期高血压组与正常晚孕组比较,年龄、孕周及新生儿出生体重无明显差异.PT、APTT、FIB下降（P〈0.05）;TT增加（P〈 0.05）.②轻度子痫前期组与正常晚孕组相比,年龄、孕周及新生儿出生体重无明显差异.PLT、PT、APTT、AT-Ⅲ、FIB降低（P〈0.05或P〈0.01）,TT、D-D、MPV升高（P〈0.05或P〈0.01）.③重度子痫前期组与正常晚孕组相比,孕周及新生儿出生体重明显降低（P〈0.01）,PLT、PT、APTT、AT-Ⅲ、FIB明显降低（P〈0.01）,TT、D-D、MPV明显升高（P〈0.01）.结论 妊娠期高血压疾病患者血液呈病理性高凝状态,且与疾病的严重程度有关

Change of coagulation function of hypertensive disorder in pregnancy and its clinical significance

Objective To compare the coagulation status between normal term pregnant women and patients with hypertensive disorder in pregnancy, and investigate the relationship between coagulation-related parameters and severity of disease. Methods The blood samples and the newborn baby＇s weight were collected from 110 patients with hypertensive disorder in pregnancy （include 42 gestational hypertensive women,27 mild preeclampsia women,41 severe preeclampsia women） and 50 normally term pregnant women. PLT,MPV,PT,TT,APTT,FIB,D-D and AT-Ⅲ were measured. Results ①Compared with the the normal term pregnant women,age,gestational weeks and birth weight had no difference,the level of PT,APTT and FIB in gestational hypertensive women were significantly decreased（P〈0.05 ）,while that of TI＂ was significantly increased（P〈0.05）.② Compared with the normal term pregnant women,age,gestational weeks and birth weight had no difference, the level of PLT, PT ,APTT ,AT-Ⅲ and FIB in mild preeclampsia were decreased（P〈0.05 ）,while that of TT, D-D and MPV were increased（P〈 0.05）. ③Compared with the normal term pregnant women ,the gestational weeks and birth weight in severe preeelampsia were significantly decreased （P〈0.01）, the level of PLT, PT, APTT, AT-Ⅲ and FIB were significantly decreased （P〈0.01 ）, while that of TT,D-D and MPV were increased（P〈0.05）. Conclusion There are pathological hypercoagulative state in pregnant women with hypertensive disorders, and which are related to severity of disease.