2型糖尿病患者血清内脂素与糖脂代谢的相关性研究

目的 探讨2型糖尿病(T2DM)患者血清内脂素与糖脂代谢的关系.方法 采用ELISA法检测110例T2DM患者(T2DM组)和80例正常体检者(对照组)的血清内脂素水平,同时检测两组患者血糖、血脂代谢参数水平.结果 T2DM组非肥胖亚组与肥胖亚组的血清内脂素水平分别高于对照组肥胖组与非肥胖亚组(P<0.01,t=-26.545,15.111,25.017,14.764);T2DM组、对照组的非肥胖亚组和肥胖亚组间血清内脂素水平差异无统计学意义(P>0.05,t=0.760,1.506);T2DM患者血清内脂素水平分别与腰臀比(WHR)、FBG、糖化血红蛋白A1c(HbA1c)、胰岛素抵抗指数(HOMA-IR)、TC、LDL-C呈显著正相关,而与HDL-C呈显著负相关(P<0.01).元逐步同归分析结果显示腰臀比(WHR)和HbA1c是影响内脂素水平的最为显著的因素(R2=0.531,0.042).结论 T2DM患者体内增高的内脂素与糖脂代谢密切相关,可能是联系糖脂代谢的重要脂肪细胞因子.

Associations between Serum Visfatin and Glucose and Lipid Metabolism in Type 2 Diabetes

Objective To investigate the relationships between serum visfatin and glucose and lipid metabolism in type 2 diabetes (T2DM). Methods ELISA method was employed to measure the serum vifatin levels between 110 T2DM cases (T2DM group) and 80 healthy controls (control group), and the levels of the indices of the glucose and lipid metabolism were detemined. Results The semm levels of the visfatin were considerably higher in both the non-obese and obese subgroup in T2DM group than those in the control group, showing significant differences between two groups(P< 0.01, t=26.545, 15.111, 25.017, 14.764 respectively). No significant differences were noted between the non-obese and obese subgroup in both two groups (P> 0.05,t=0.760,1.506). The level of the visfafin was positively related to WHR,FBG, HbA1c,HOMA-IR,TC and LDL-C in the T2DM group and negatively to HDL-C,all P< 0.01. Multiple stepwise regression results showed that WHR and HbA1c were predominant factors affeeting the visfatin levels(R2=0.547,0.033 respectively). Conelusion Increased visfatin proves to be directly associated with glucose and lipid metabolism in T2DM, acting as one of the major adipoeytokines connecting the glucose and lipid metabolism.