丙烯酸-泊洛沙姆407共聚物的合成及其原位胶凝性质

目的制备丙烯酸和泊洛沙姆407构成的共聚物,研究其温度敏感的原位胶凝性质。方法将泊洛沙姆407溶于丙烯酸单体,引发聚合反应,产物用红外光谱和凝胶渗透色谱表征。用旋转黏度计测定共聚物水溶液的黏度随温度的变化。以维生素B12为模型药物,研究药物的释放性质。结果较低浓度的丙烯酸泊洛沙姆407共聚物水溶液具有受热原位胶凝的性质,其胶凝特征与共聚物的组成、浓度、溶液pH等有关,共聚物凝胶可延缓药物释放。结论丙烯酸泊洛沙姆407共聚物可望应用于黏膜给药的原位凝胶递药系统。

Synthesis and in situ gelling properties of acrylic acid-poloxamer 407 copolymers

Objective To synthesize copolymers composed of polyacrylic acid and poloxamer 407,and investigate its thermo-sensitive gelling properties in situ.Methods Copolymers of acrylic acid-poloxamer 407 were prepared by free-radical polymerization after dissolving poloxamer 407 in acrylic acid.The copolymers were characterized by FTIR and GPC,and the viscosity of its aqueous solution was measured by rotatory viscometer as functions of temperature.Vitamin B12 was selected as a model drug and the in vitro release properties was studied.Results Aqueous solutions of copolymers showed thermal-reversible gelling properties at a relatively low concentration,and the gelation temperature(T_(gel)) was dependent on copolymer composition,concentration and pH of the solutions.In vitro release studies indicated that such gels could retard drug release obviously.Conclusions Such copolymer may be a candidate in situ gelling carriers for mucus drug delivery.