氯雷他定联合自体全血疗法治疗慢性荨麻疹的临床观察

目的:观察氯雷他定联合自体全血疗法治疗慢性荨麻疹的临床疗效和安全性。方法:200例慢性荨麻疹患者按随机数字表法均分为对照组和观察组。对照组患者给予氯雷他定片10 mg,口服,qd;观察组患者在对照组治疗的基础上接受自体血清静脉注射治疗,在无菌的条件下采集患者肘静脉血5 ml,加入2%利多卡因1 ml中,臀部肌肉注射,2³次/周。两组患者疗程均为4周。观察两组患者的临床疗效,治疗前后临床症状总评分,嗜酸性粒细胞比例、血清免疫球蛋白E(IgE)含量、复发率及不良反应发生情况。结果:观察组患者总有效率显著高于对照组,复发率显著低于对照组,两组比较差异均有统计学意义(P<0.05)。治疗前两组患者瘙痒程度评分、临床症状总评分、嗜酸性粒细胞比例、血清IgE含量比较,差异均无统计学意义(P>0.05);治疗后两组患者瘙痒程度评分、临床症状总评分、嗜酸性粒细胞比例、血清IgE含量均显著低于同组治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:氯雷他定联合自体全血疗法治疗慢性荨麻疹较单用氯雷他定疗效更显著,安全性较好。

Clinical Observation of Loratadine Combined with Autologous Whole Blood Injection Treatment for Chron- ic Urticaria

OBJECTIVE： To observe clinical efficacy and safety of loratadine combined with autologous whole blood injection treatment for chronic urticaria. METHODS： 200 patients with chronic urticaria were randomized into control group and observation group. Control group was given Loratadine tablet 10 mg orally, once a day. Observation group was additionally given autologous whole blood injection treatment on the basis of control group： ulnar vein blood 5 ml added into 2% lidocaine 1 ml for intramuscu- lar injection at buttocks under aseptic conditions, twice or 3 times a week. Both groups were given 4 weeks of continuous treat- ment. Clinical efficacies of 2 groups were observed, and total symptom score, eosinophils proportion, immunoglobulin E （Ig E） content, recurernce rate and the occurrence of ADR were observed before and after treatment. RESULTS： Total effective rate of ob- servation group was significantly higher than that of control group, while recurernce rate was significantly higher than in control group; there was statistical significance （P〈0.05）. There was no statistical significance in pruritus score, total symptom score, eo- sinophils proportion and Ig E content between 2 groups before treatment （P〉0.05） ; those index of 2 groups after treatment were significantly lower than before; the observation group was lower than the control group; there was statistical significance （P〈 0.05）. There was no statistical significance in the incidence of ADR in 2 groups （P〉0.05）. CONCLUSIONS： The loratadine com- bined with autologous whole blood injection treatment is better than loratadine alone for chronic urticaria in therapeutic efficacy and safety.