| 小剂量顺铂增强放疗诱导HeLa细胞凋亡的实验研究 |
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| 引用本文： | 程玉峰,乔乃安,刘宏,梁业民,江森.小剂量顺铂增强放疗诱导HeLa细胞凋亡的实验研究[J].现代妇产科进展,2002,11(6):413-414. |
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| 作者姓名： | 程玉峰 乔乃安 刘宏 梁业民 江森 |
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| 作者单位： | 1. 山东大学齐鲁医院肿瘤防治中心,济南,250012
2. 山东大学齐鲁医院妇产科,济南,250012 |
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| 摘 要： | 目的 :实验研究小剂量顺铂增强放疗诱导HeLa细胞凋亡的作用。方法 :将细胞分为单纯放疗组、单纯化疗组、放疗加化疗组和空白对照组 4组 ,采用TUNEL法分别检测各组细胞的凋亡率。结果 :单纯放疗、化疗都可诱导HeLa细胞凋亡 ,顺铂 (化疗 )可以明显增强放疗诱导的细胞凋亡。结论 :小剂量顺铂可明显增加放疗诱导的HeLa细胞凋亡 ,为临床应用小剂量顺铂使放疗增效提供了理论依据
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| 关 键 词： | 顺铂 放射疗法 HeLa细胞 细胞凋亡 实验 |
| 文章编号： | 1004-7379(2002)06-0413-02 |
| 修稿时间： | 2002年9月23日 |
Experimental study of the low dose cisplatin enhancing the apoptosis of HeLa cell induced by radiotherapy |
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| Cheng Yufeng,Qiao Naian,Liu Hong,et al..Experimental study of the low dose cisplatin enhancing the apoptosis of HeLa cell induced by radiotherapy[J].Current Advances In Obstetrics and Gynecology,2002,11(6):413-414. |
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| Authors: | Cheng Yufeng Qiao Naian Liu Hong |
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| Affiliation: | Cheng Yufeng,Qiao Naian,Liu Hong,et al.Center of tumor prevention and treatment,the Qilu Hospital of Shandong University,Jinan 250012 |
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| Abstract: | Objective:To study experimentally the enhancement of low dose cisplatin of the apoptosis of HeLa cell induced by radiotherapy(RT).Methods:The HeLa cells were divided into four groups treated with RT alone,chemotherapy (ChT) alone,RT combined with ChT group and control group.the rates of HeLa cell apoptosis were detected by a modified in situ TUNEL technique.Results: RT and ChT could induce HeLa cell apoptosis,cisplatin (ChT) could obviously enhance HeLa cell apoptosis induced by RT. Conclusions:Low dose cisplatin can obviously enhance HeLa cell apoptosis induced by RT.The study provides the academic proof for clinical use of low dose cisplatin enhancing cell apoptosis induced by RT. |
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| Keywords: | Cisplatin Radiotherapy HeLa cells Cell apoptosis Experiments |
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