| 日本血吸虫云南品系SIEA对小鼠感染皖鄂品系血吸虫的免疫保护作用(英文) |
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| 引用本文： | 李翠英,陈连勇,贾雪梅,王红,曾瑾,李飞.日本血吸虫云南品系SIEA对小鼠感染皖鄂品系血吸虫的免疫保护作用(英文)[J].中国病原生物学杂志,2011(4). |
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| 作者姓名： | 李翠英 陈连勇 贾雪梅 王红 曾瑾 李飞 |
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| 作者单位： | 昆明医学院寄生虫学教研室;云南省疾病预防控制中心; |
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| 基金项目： | Science Research Fund of the Education Office of Yunnan Province,China(No.08Y0206) |
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| 摘 要： | 目的观察日本血吸虫云南品系未成熟卵可溶性抗原SIEA免疫小鼠后攻击感染皖鄂品系血吸虫尾蚴,是否也能诱导出免疫保护效果。方法 20只ICR小鼠随机分为免疫组和对照组,经日本血吸虫云南品系SIEA免疫后攻击感染皖鄂品系血吸虫尾蚴,感染后46 d观察减虫率、粪卵减少率、雌虫子宫内虫卵数、肝表面虫卵结节数、肝脏各期虫卵数及各期虫卵构成比。结果 SIEA免疫后粪卵及雌虫子宫内虫卵减少率分别为34.45%,23.69%(P<0.05);肝表面虫卵结节密度下降29.03%(P<0.05);肝组织内虫卵减少29.07%(P<0.05),成熟虫卵减少48.41%(P<0.05)。肝组织内成熟虫卵比例下降,未成熟卵比例增加(P<0.05)。结论日本血吸虫(云南品系)未成熟卵可溶性抗原(SIEA)的抗原性较强,小鼠经云南品系SIEA免疫后攻击感染皖鄂品系血吸虫尾蚴也诱导小鼠产生了抗卵胚发育及抗雌虫生殖免疫力,结果提示将来在中国大陆使用SIEA疫苗时,似可不必考虑血吸虫品系的影响。
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| 关 键 词： | 血吸虫 日本 品系 血吸虫病 卵 抗卵胚发育 抗生殖作用 |
IMMUNE PROTECTION IN MICE PROVIDED BY SIEA OF A YUNNAN ISOLATE OF SCHISTOSOMA JAPONICUM BUT CHALLENGED WITH ANOTHER ISOLATE |
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| LI Cui-ying ,CHEN Lian-yong,JIA Xue-mei,WANG Hong,ZENG Jin,LI Fei.IMMUNE PROTECTION IN MICE PROVIDED BY SIEA OF A YUNNAN ISOLATE OF SCHISTOSOMA JAPONICUM BUT CHALLENGED WITH ANOTHER ISOLATE[J].Journal of Pathogen Biology,2011(4). |
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| Authors: | LI Cui-ying CHEN Lian-yong JIA Xue-mei WANG Hong ZENG Jin LI Fei |
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| Affiliation: | LI Cui-ying 1,CHEN Lian-yong2,JIA Xue-mei1,WANG Hong1,ZENG Jin1,LI Fei1***(1.Parasitology Department,Kunming Medical College,Kunming,Yunnan 650031,China,2.Yunnan Centers For Disease Control And Prevention) |
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| Abstract: | Objective To observe the protective effect induced by soluble immature egg antigen(SIEA) of a Yunnan isolate of Schistosoma japonicum in mice challenged with a Wan'e isolate.Methods Twenty ICR mice were immunized with SIEA of the Yunnan isolate of S.japonicum but were challenged with cercariae of the Wan'e isolate.On day 46 after infection,mice were sacrificed and different indices were compared with those from the control group.The indices included worm reduction,the rate of egg reduction in feces,the fema... |
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| Keywords: | Schistosoma japonicum isolate schistosomiasis ovum anti-embryonation anti-fecundity |
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