| 青霉素制备青霉素亚砜的研究 |
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| 引用本文： | 史兰香,陈焕章,赵地顺,徐志栋,荣杰.青霉素制备青霉素亚砜的研究[J].精细化工,2000,17(5):252-255,276. |
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| 作者姓名： | 史兰香 陈焕章 赵地顺 徐志栋 荣杰 |
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| 作者单位： | 河北科技大学,化学与制药工程系,河北,石家庄,050018 |
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| 基金项目： | 河北省科委资助项目! ( 972 1 3 0 52D) |
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| 摘 要： | 以青霉素G钾盐与低质量分数过氧乙酸为原料氧化制备青霉素亚砜 ,其最佳工艺条件为 :n(C16 H18N2 O4 SK)∶n(CH3CO3H) =1 .0∶( 1 1～ 1 2 ) ,反应温度 0～ 5℃ ,反应时间 2 .0～ 2 5h ,w(CH3CO3H) =8 5% ,w(CH3CO2 H) =1 0 %。青霉素亚砜收率达 96 8%。同时建立了青霉素亚砜的半定量分析方法 ,以硅胶G为固定相 ,以V(CH3CO2 C4 H9 n)∶V(CH3CO2 H)∶V(NaH2 PO4 -H2 O)∶V(C4 H9OH n) =6.0∶2 .0∶1 .0∶0 5为流动相 ,用TLC法对产品进行半定量分析检测 ,并经IR、MS谱图验证了产品结构。
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| 关 键 词： | 青霉素 青霉素亚砜 青霉素G |
Preparation of Penicillin G S-Oxide from Penicillin G |
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| SHI Lan-xiang,CHEN Huan-zhang,ZHAO Di-shun,XU Zhi-dong,RONG Jie.Preparation of Penicillin G S-Oxide from Penicillin G[J].Fine Chemicals,2000,17(5):252-255,276. |
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| Authors: | SHI Lan-xiang CHEN Huan-zhang ZHAO Di-shun XU Zhi-dong RONG Jie |
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| Affiliation: | SHI Lan-xiang,CHEN Huan-zhang,ZHAO
Di-shun,XU Zhi-dong,RONG Jie;
(Department of Chemical and Pharmaceutical Engineering,Hebei University of Science and
Technology,Shijiazhunag 050018,China) |
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| Abstract: | Penicillin G S oxide was synthesized with penicillin G and acetic hydroperoxide of low concentration.The optimal reaction conditions were as follows:mole ratio of penicillin G∶acetic hydroperoxide=1.0∶(1.1-1.2),reaction temperature 0-5 ℃,reaction time 2.0-2.5 h,concentration of acetic hydroperoxide 8 5%,concentration of acetic acid 10%.The yield of product was 96 8%.Moreover,the method of thin layer chromatography for identification of penicillin G S oxide was established with mobile phase of n butyl acetate-acetic acid-sodium dihydrogen phosphate n butanol(6.0∶2.0∶1.0∶0 5 by volume).The structure of the product was identified with IR and MS. |
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| Keywords: | penicillin penicillin G S oxide penicillin G Foundation Item:Granted by Hebei province science and technology committee(97213052D) |
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