| 多巴胺D2受体基因-141C Ins/Del多态性与海洛因依赖的关系 |
| |
| 引用本文： | 邵春红 李一峰 江开达 赵敏 林凌 宋立升 徐一峰 朱敏 王秋颖 周伟航. 多巴胺D2受体基因-141C Ins/Del多态性与海洛因依赖的关系[J]. 中国行为医学科学, 2005, 14(10): 885-886 |
| |
| 作者姓名： | 邵春红 李一峰 江开达 赵敏 林凌 宋立升 徐一峰 朱敏 王秋颖 周伟航 |
| |
| 作者单位： | 复旦大学附属华山医院精神医学教研室，复旦大学生命学院遗传所，上海市精神卫生中心，上海市精神卫生中心，复旦大学生命学院遗传所，上海市精神卫生中心，上海市精神卫生中心，上海市精神卫生中心，上海市精神卫生中心，上海市禁毒委员会办公室 200040上海 |
| |
| 摘 要： | 目的分析多巴胺D2受体(DRD2)基因-141CIns/Del多态是否与海洛因成瘾易感性有关。方法采用PCR-RFLP技术检测380名海洛因依赖者(依赖组)和275名健康对照者(对照组)的DRD2-141CIns/Del基因多态,比较依赖组和对照组DRD2-141CIns/Del多态基因型及等位基因频率是否有差异。结果依赖组与对照组相比,DRD2-141CIns/Del的基因型频率(Del/Del:4.3vs6.5;Ins/Del:24.8vs27.2;Ins/Ins:70.9vs66.2)和等位基因频率(Del:23.6vs20.2;Ins:76.4vs79.8)差异均无显著性(分别为2=2.789,P=0.248;2=2.103,P=0.210)。结论DRD2-141CIns/Del基因多态与海洛因成瘾易感性可能无关。
|
| 关 键 词： | 海洛因依赖 多巴胺D_2受体 多态性 |
| 修稿时间： | 2005-04-18 |
Relationship between DRD2 receptor gene-141C Ins/Del polymorphism and heroin dependence |
| |
| SHAO Chun-hong,LI Yi-feng,JIANG Kai-da,et al.. Relationship between DRD2 receptor gene-141C Ins/Del polymorphism and heroin dependence[J]. Chinese Journal of Behavioral Medical Science, 2005, 14(10): 885-886 |
| |
| Authors: | SHAO Chun-hong LI Yi-feng JIANG Kai-da et al. |
| |
| Affiliation: | SHAO Chun-hong,LI Yi-feng,JIANG Kai-da,et al. Department of Psychiatry,Huashan Hospital,Fudan University,Shanghai 200040,China |
| |
| Abstract: | ObjectiveTo analyze the relationship between DRD_2receptor gene-141C Ins/Del polymorphism and heroin dependence.MethodThe polymorphism of DRD_2-141CIns/Del was detected by using PCR-RFLP for 380 heroin addicts who were abstinent (dependence group) and 275 normal controls (control group) using PCR-RFLP. The genotypes and alleles of DRD_ 2-141CIns/Del between dependence group and control group.ResultsCompared with control group, no significant difference of genotypes and alleles of DRD_2-141CIns/Del had been found in dependence group ( 2 = 2.789,P = 0.248; 2 = 2.103,P= 0.210,respectively). Conclusion DRD_2 receptor gene -141C Ins/Del polymorphism may have no association with the susceptibility of heroin dependence. |
| |
| Keywords: | Heroin dependence Dopamine D_2 receptor Polymorphism |
| 本文献已被 CNKI 等数据库收录！ |
