米根霉发酵生产L(+)-乳酸研究进展

米根霉是生产绿色平台生物化学品L(+) 乳酸的理想菌种 ,目前集中在发酵工艺的优化、新型生物反应器的设计以及细胞固定化等方面的研究 ,通过控制米根霉菌体形态使之自聚集成为一定大小的球体进行乳酸发酵 ,操作简便、费用低。建议今后从应用代谢工程技术定向选育米根霉L(+) 乳酸高产菌 ,改进发酵设备、改良提取工艺 ,合理控制乳酸产品的构型等几个方面着手进行进一步研究 ,从而降低乳酸生产原料的成本 ,扩大L(+) 乳酸的应用领域。

Advances in fermentation of green platform biochemical L(+)-lactic acid by Rhizopus oryzae

Rhizopus oryzae is a preferable species for its outstanding ability to directly produce almost optically pure L (+) lactic acid (a green platform biochemical) from starch with low nutritional requirement.Studies on L (+) lactic acid fermentation are focused on the optimization of fermentation technology,the design of new bioreactor and cell immobilization,etc.The production of L (+) lactic acid using the pellet form of Rhizopus oryzae has gotten more attention because it can be easily operated and has better performance.Breeding L (+) lactic acid over production strain by metabolic engineering technology,improving the fermentation and separation equipment and technology,controlling the configuration of lactic acid rationally,will greatly reduce the cost and extend the use of L (+) lactic acid.