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| 超临界流体增强溶液分散度法制备阿莫西林缓释微囊 | |
| 引用本文： | 陈岚,张岩,李保国,伍贻文,华泽钊,刘哲鹏,陆伟跃.超临界流体增强溶液分散度法制备阿莫西林缓释微囊[J].化学工程,2006,34(1):70-73,78. |
| 作者姓名： | 陈岚 张岩 李保国 伍贻文 华泽钊 刘哲鹏 陆伟跃 |
| 作者单位： | 1. 上海理工大学,医疗器械学院,上海,200093 2. 上海理工大学,动力工程学院,上海,200093 3. 复旦大学,药学院,上海,200032 |
| 基金项目： | 国家自然科学基金(59836240)，上海市教委重点学科建设项目共同资助 |
| 摘 要： | 采用超临界流体增强溶液分散度法,对制备阿莫西林-乙基纤维素-卡波谱缓释微囊进行了初步研究,探索了制备微米级缓释药物微囊的新方法。在对制备乙基纤维素空白微粒影响因素研究的基础上,选择了较为适合的工艺参数:CO2流速0.42 m/s,温度40℃,压力9.0或12.0 MPa。在2种压力下分别得到平均粒径为5.48μm和2.85μm的药物微囊,其载药量为9.53%和9.70%,同时还考察了制得微囊药物的释放度曲线,结果表明阿莫西林微囊具有明显的缓释效果。超临界流体增强溶液分散度法是制备微米级药物微囊的极有前途的方法。 |
| 关 键 词： | 超临界流体增强溶液分散度法 乙基纤维素 阿莫西林 微囊 |
| 文章编号： | 1005-9954（2006）01-0070-04 |
Preparation of amoxicillin microcapsules by using solution enhanced dispersion of supercritical fluids process |
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| CHEN Lan,ZHANG Yan,LI Bao-guo,WU Yi-wen,HUA Ze-zhao,LIU Zhe-peng,LU Wei-yue.Preparation of amoxicillin microcapsules by using solution enhanced dispersion of supercritical fluids process[J].Chemical Engineering,2006,34(1):70-73,78. | |
| Authors: | CHEN Lan ZHANG Yan LI Bao-guo WU Yi-wen HUA Ze-zhao LIU Zhe-peng LU Wei-yue |
| Affiliation: | 1. College of Medical Apparatus and Instruments, University of Shanghai for Science and Technology, Shanghai 200093, China; 2. College of Power Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; 3. Medical Center, Fudan University, Shanghai 200032, China |
| Abstract: | The characteristics of sustained-releasing amoxicllin-ethylcellulose-carbopol microcapsules,prepared by the Solution Enhanced Dispersion by Supercritical fluids(SEDS) process,were studied.A new method for (pharmaceutical) microcapsule preparation was investigated.Based on the investigation of the microparticle formation of ethylcellulose,the suitable experimental parameters of microcapsule formation such as velocity of CO_2(0.42 m/s),temperature(40℃) and pressures(9 and 12 MPa) were selected.Under the different pressures,the(microcapsules′) diameters are 5.48 μm and 2.85 μm,and the contents of drug are 9.53% and 9.70% respectively.And the drug releases were also measured.The results of the experiment indicate that the microcapsules have the sustained-release properties;the SEDS process is a promising method to prepare microcapsules of drugs. |
| Keywords: | solution enhanced dispersion by supercritical fluids ethylcellulose amoxicillin microcapsule |
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