| 慢性不可预见性应激对大鼠神经递质及下丘脑-垂体-肾上腺皮质轴的影响 |
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| 引用本文： | 杨亦龙,姚晓泉,王雅丽,王海征,欧阳俊,刘思思,王蕾,张秋霞,赵晖.慢性不可预见性应激对大鼠神经递质及下丘脑-垂体-肾上腺皮质轴的影响[J].首都医学院学报,2015(1):127-131. |
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| 作者姓名： | 杨亦龙 姚晓泉 王雅丽 王海征 欧阳俊 刘思思 王蕾 张秋霞 赵晖 |
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| 作者单位： | 首都医科大学中医药学院中医临床基础学系 中医络病研究北京市重点实验室,北京,100069 |
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| 基金项目： | 北京市教委基金(KM201310025013)；北京市属高等学校高层次人才引进与培养计划-长城学者项目资助(CIT&TCD20140329)。This study was supported by the Fund of Commission of Education of Beijing(KM201310025013)；Program for Changcheng Scholars of the Importation and Devel-opment of High-Caliber Talents Project of Beijing Municipal Institutions (CIT&TCD20140329)． |
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| 摘 要： | 目的探讨慢性不可预见性应激(chronic unpredictable stress,CUS)对大鼠神经递质和下丘脑-垂体-肾上腺皮质轴(hypothalamic-pituitary-adrenal axis,HPA)的影响。方法 16只SD雄性大鼠随机数字表法分为正常对照组和模型组。模型组大鼠给予慢性不可预见性的应激,检测其体质量增长量;通过蔗糖偏嗜实验观察大鼠行为学的改变;采用高效液相-电化学法测定海马多巴胺(dopamine,DA)、5-羟色胺(5-hydroxytryptamine,5-HT),高效液相-荧光法测定谷氨酸(glutamic acid,Glu)、γ-氨基丁酸(γ-aminobutyric acid,γ-GABA);用放射免疫法检测血浆及下丘脑促肾上腺皮质激素释放激素(corticotropin-releasing hormone,CRH)、促肾上腺皮质激素(adrenocorticotropic hormone,ACTH)、皮质酮(corticosterone,CORT)。结果与正常对照组相比,模型组大鼠体质量增长量显著降低,糖水消耗量明显下降,DA、γ-GABA显著降低,5-HT、Glu有升高的趋势,ACTH显著降低,CORT质量浓度明显增高。结论 CUS会导致大鼠行为学的改变,HPA轴的紊乱。
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| 关 键 词： | 慢性不可预见性应激 行为学 神经递质 下丘脑-垂体-肾上腺皮质轴 |
Effect of chronicunpredictable stress on neurotransmitter and hypothalamic-pituitary-adrenal axis in rats |
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| Yang Yilong,Yao Xiaoquan,Wang Yali,Wang Haizheng,Ouyang Junyao,Liu Sisi,Wang Lei,Zhang Qiuxia,Zhao Hui.Effect of chronicunpredictable stress on neurotransmitter and hypothalamic-pituitary-adrenal axis in rats[J].Journal of Capital University of Medical Sciences,2015(1):127-131. |
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| Authors: | Yang Yilong Yao Xiaoquan Wang Yali Wang Haizheng Ouyang Junyao Liu Sisi Wang Lei Zhang Qiuxia Zhao Hui |
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| Affiliation: | Yang Yilong;Yao Xiaoquan;Wang Yali;Wang Haizheng;Ouyang Junyao;Liu Sisi;Wang Lei;Zhang Qiuxia;Zhao Hui;Department Traditional Chinese Medicine Clinical Basis,School of Traditional Chinese Medicine,Capital Medical University,Beijing Key Laboratory of TMC Collateral Disease Theory Research; |
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| Abstract: | |
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| Keywords: | chronic-unpredictable-stress behavior neurotransmitter hypothalamic-pituitary-adrenal axis |
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