| 左-卡尼汀对缺血心肌的保护作用 |
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| 引用本文： | 姚丽红.左-卡尼汀对缺血心肌的保护作用[J].心血管病学进展,2010,31(5):763-766. |
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| 作者姓名： | 姚丽红 |
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| 作者单位： | 辽宁医学院附属第一医院心内科,辽宁,锦州,121001 |
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| 摘 要： | 左-卡尼汀又名肉碱,是脂肪酸进行β-氧化必不可少的载体。正常情况下,心肌能量总需量的60%～90%由游离脂肪酸进行β-氧化所提供。心肌细胞缺血缺氧时,氧化磷酸化功能下降,内源性左-卡尼汀合成障碍,引起心肌的一系列代谢改变。近年来研究认为左-卡尼汀通过不同的机制对缺血心肌具有保护作用。
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| 关 键 词： | 左-卡尼汀 心肌代谢 心肌缺血 保护 |
L-carnitine and Ischemic Myocardial Protection |
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| YAO Li-hong.L-carnitine and Ischemic Myocardial Protection[J].Advances in Cardiovascular Diseases,2010,31(5):763-766. |
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| Authors: | YAO Li-hong |
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| Affiliation: | YAO Li-hong,LU Hong(Department of Cardiology,The First Affiliated Hospital of Liaoning Medical College,Jinzhou 121001,China) |
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| Abstract: | L-carnitine,also known as novain,carries fatty acids from the cytosol to the mitochondria during lipid breakdown.Under normal circumstances,60%～90% of total amount of cardiac energy that need to be measured provided by leave fatty acids carrying on β-oxidize.When myocardial cell lacked blood anoxia,oxidize phosphoric acid function is descending,and inside source L-carnitine synthesization has obstacles.It causes a series of metabolism change of myocardium.Recent studies suggest that L-carnitine has a protective effect during myocardial ischemia. |
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| Keywords: | L-carnitine myocardial metabolism myocardial ischemia protection |
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