重度子痫前期患者肝功能损害与围产儿结局的相关性研究

目的 分析重度子痫前期患者肝功能损害与围产儿结局的相关性.方法 回顾性分析114例重度子痫前期合并肝功能损害患者(观察组)及同时期100例重度子痫前期未合并肝功能损害患者(对照组)、正常住院分娩的100例孕妇(正常组)的临床资料,比较观察组与正常组血清谷氨酸转氨酶(alanine aminotransferase,ALT)、天冬氨酸氨基转移酶(aspartate aminotransferase,AST)、r-谷氨酰转肽(glutamyl transferase,GGT)水平,并比较观察组与对照组的围产儿结局,采用线性回归分析,分析血清ALT、AST、GGT与围产儿结局的相关性.结果 观察组血清ALT、AST、GGT水平均显著高于正常组,差异具有统计学意义(P＜0.05);观察组胎儿生长受限、早产、围产儿死亡、胎盘早剥、死胎的发生率均大于对照组,差异具有统计学意义(P＜0.05);血清ALT、AST、GGT水平与胎儿生长受限、早产和围产儿死亡发生率呈正相关(P＜0.05).结论 重度子痫前期患者肝功能损害与围产儿结局的发生、发展具有明显的相关性,随着肝功能损害程度增大,可能导致胎儿生长受限、早产、围产儿死亡等不良围产儿结局发生.

Study on the Relationship Between Liver Function Damage and Perinatal Outcome in Patients with Severe Preeclampsia

Objective To analyze the correlation between liver function damage and perinatal outcome in patients with severe preeclampsia.Methods 114 cases of severe preeclampsia complicated with liver function damage in patients (observation group),the same period 100 cases of severe preeclampsia patients with hepatic impairment(control group) and 100 cases of normal pregnant women hospitalized delivery (control normal group) were selected.Retrospectively analysis was used for analyzing normal serum glutamic acid transaminase (alanine aminotransferase,ALT),aspartate aminotransferase (aspartate aminotransferase,AST),glutamyl peptide (glutamyl transferase,GGT) level in the observation group and the control group.The surrounding and perinatal outcomes were compared between the observation group and the control group.Linear regression analysis was used to analyze the correlation between serum levels of ALT,AST,GGT and perinatal outcome.Results The serum levels of ALT,AST and GGT levels were significantly higher than the control group (P ＜ 0.05).Fetal growth restriction,premature birth,perinatal death,placental abruption,fetal death rate in observation group were significantly higher than those in the control group (P ＜ 0.05).Serum ALT,AST,GGT levels and fetal growth restriction,premature birth and perinatal death rate was positively correlated (P ＜ 0.05).Conclusion A clear correlation was found between liver dysfunction and perinatal outcome of the occurrence and development in severe preeclampsia patients.The progression of liver damage might lead to fetal growth restriction,premature birth,perinatal death and other adverse perinatal outcome.