| 2-氨基-5-芳基-1,3,4-噁二唑的合成 |
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| 引用本文： | 尹大伟,王龙瑞,刘玉婷,李金泽,刘英.2-氨基-5-芳基-1,3,4-噁二唑的合成[J].精细石油化工,2022,39(1):18-22. |
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| 作者姓名： | 尹大伟 王龙瑞 刘玉婷 李金泽 刘英 |
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| 作者单位： | 陕西科技大学前沿科学与技术转移研究院 ,陕西西安 710021;陕西科技大学化学与化工学院 ,教育部轻化工助剂化学与技术重点实验室 ,陕西西安710021;陕西科技大学化学与化工学院 ,教育部轻化工助剂化学与技术重点实验室 ,陕西西安710021 |
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| 基金项目： | 国家自然科学基金项目(No.21706152);陕西省科技计划项目(No.2021GY-162)。 |
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| 摘 要： | 以(取代)苯甲醛及盐酸氨基脲为原料,合成了中间体芳醛缩氨脲。再以1,4-二氧六环为溶剂,在无水碳酸钾与碘的作用下反应得到2-氨基-5-芳基-1,3,4-噁二唑。实验结果表明,2-氨基-5-芳基-1,3,4噁二唑优化合成条件为:n(苯甲醛缩氨脲)∶n(无水碳酸钾)∶n(碘)=1.0∶1.5∶0.6,反应温度80℃,反应时间6 h,产率84%以上。
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| 关 键 词： | 2-氨基-5-芳基-1 3 4-噁二唑 苯甲醛缩氨脲 合成 |
SYNTHESIS OF 2-AMINO-5-ARYL-1,3,4-OXADIAZOLE |
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| Yin Dawei,Wang Longrui,Liu Yuting,Li Jinze,Liu Ying.SYNTHESIS OF 2-AMINO-5-ARYL-1,3,4-OXADIAZOLE[J].Speciality Petrochemicals,2022,39(1):18-22. |
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| Authors: | Yin Dawei Wang Longrui Liu Yuting Li Jinze Liu Ying |
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| Affiliation: | (Institute of Frontier Science and Technology Transfer, Shaanxi University of Science & Technology, Xi’an 710021, Shaanxi, China;College of Chemistry and Chemical Engineering,Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science & Technology, Xi’an 710021, Shaanxi, China) |
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| Abstract: | The aromatic aldehyde semicarbazone intermediates were synthesized using arylaldehyde and semicarbazide hydrochloride as raw materials,and then 2-amino-5-aryl-1,3,4-oxadiazole were synthesized using arylaldehyde semicarbazone in 1,4-dioxane in the presence of iodine and anhydrous K2CO3.The reaction conditions were optimized,the best synthetic conditions for 2-amino-5-aryl-1,3,4 oxadiazole are:the n(semicarbazone)∶n(anhydrous K2CO3)∶n(iodine)ratio is 1.0∶1.5∶0.6,the reaction temperature is 80℃,the reaction time is 6 h,and the yield is above 84%. |
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| Keywords: | 2-amino-aryl-1 3 4-oxadiazole derivatives arylaldehyde semicarbazone synthesis |
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