| 防己黄芪汤对阿霉素肾病模型大鼠肾组织IL-6、TGF-β1的影响 |
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| 引用本文： | 张常明,范颖,陈晶晶,林庶茹.防己黄芪汤对阿霉素肾病模型大鼠肾组织IL-6、TGF-β1的影响[J].辽宁中医学院学报,2011(8):99-101. |
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| 作者姓名： | 张常明 范颖 陈晶晶 林庶茹 |
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| 作者单位： | [1]辽宁中医药大学方剂学科,辽宁沈阳110032 [2]辽宁中医药大学中医分子生物学实验室,辽宁沈阳110032 |
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| 基金项目： | 辽宁省科技厅课题（2009225010-37） |
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| 摘 要： | 目的：考察防己黄芪汤干预阿霉素肾病模型大鼠的效应强度,初步探讨其作用机制。方法：按5mg/kg体重给予大鼠尾静脉1次注射阿霉素建立阿霉素肾病模型;检测尿蛋白量,ELISA法检测肾组织IL-6、TGF-β1浓度。结果：模型组大鼠尿蛋白定量升高,肾组织IL-6浓度增加、TGF-β1浓度降低（P〈0.05）;防己黄芪汤高、中、低剂量组尿蛋白定量明显减少（P〈0.05）,肾组织IL-6浓度降低、TGF-β1浓度升高（P〈0.05）。结论：防己黄芪汤对阿霉素肾病模型大鼠肾功能具有一定的保护作用,可能与其降低肾组织IL-6浓度、提高肾组织TGF-β1浓度有关。
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| 关 键 词： | 防己黄芪汤 蛋白尿 白介素-6 TGF-β1 |
Menispermaceae Astragalus Decoction in Rats with Adriamycin Nephropathy in Renal Tissue IL-6 TGF-β1 Effects |
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| ZHANG Chang-ming,FAN Ying,CHEN Jing-jing,LIN Shu-ru.Menispermaceae Astragalus Decoction in Rats with Adriamycin Nephropathy in Renal Tissue IL-6 TGF-β1 Effects[J].Journal of Liaoning College of Traditional Chinese Medicine,2011(8):99-101. |
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| Authors: | ZHANG Chang-ming FAN Ying CHEN Jing-jing LIN Shu-ru |
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| Abstract: | Objective： To study the anti-intervention has astragalus soup adriamycin nephropathy in rats the effects of intensity,to explore its mechanism.Methods： 5mg/kg body weight in rats given doses of intravenous injection of doxorubicin once established adriamycin nephropathy;urinary protein,ELISA assay of renal tissue IL-6,TGF-β1 concentration.Results： The rats increased urinary protein,renal concentration of IL-6,TGF-β1 concentration decreased（P〈0.05）;Menispermaceae astragalus soup high,medium and low-dose group was significantly reduced urinary protein excretion（P〈0.05）,renal reduce the concentration of IL-6,TGF-β1 concentration（P〈0.05）.Conclusion： Astragalus soup has anti-adriamycin nephropathy renal function has a protective effect may be related to reduced renal IL-6 concentration,increased renal TGF-β1 concentration. |
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| Keywords: | Menispermaceae astragalus soup proteinuria interleukin-6 TGF- β1 |
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