Linking Sepsis with chronic arterial hypertension,diabetes mellitus,and socioeconomic factors in the United States: A scoping review |
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| Affiliation: | 1. Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA;2. The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA;3. Harrison Medical Library, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA;4. Division of Pulmonary and Critical Care Medicine, the Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA;1. Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy;2. Department of Anesthesia, Critical Care and Emergency, Spedali Civili University Hospital, Brescia, Italy;3. Department of Emergency and Intensive Care, ASST Monza, Monza, Italy;4. Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy;5. “Alessandra BONO” University Research Center on LOng Term Outcome (LOTO) in Survivors of Critical Illness, University of Brescia, Italy;1. Service de médecine intensive-réanimation, Hôpital Cochin, Assistance Publique - Hôpitaux de Paris Centre, 27 rue du faubourg Saint Jacques, 75014 Paris, France;2. Université Paris Cité, Paris, France;3. Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Cité, 22 rue Méchain, 75014 Paris, France;4. Service de médecine intensive-réanimation, Hôpital Privé de l''Ouest Parisien, Ramsay Générale de Santé, 14 Rue Castiglione del Lago, 78190 Trappes, France;5. Centre de Recherche en Epidémiologie et Santé des Populations, Team 5 (EpReC, Renal and Cardiovascular Epidemiology), INSERM U-1018, Université de Versailles Saint-Quentin, 16, avenue Paul Vaillant Couturier, 94807 Villejuif, France;1. Department of Intensive Care, Austin Hospital, Melbourne, Australia;2. Department of Intensive Care, Northern Hospital, Melbourne, Australia;3. Department of Critical Care, University of Melbourne, Melbourne, Australia;4. Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia;5. Data Analytics Research & Evaluation (DARE) Center, University of Melbourne and Austin Hospital, Melbourne, Australia;6. Department of Critical Care Medicine, Hospital Israelita Albert Einstein, Sao Paulo, Brazil;1. Sorbonne University, GRC 29, AP-HP, DMU DREAM and Department of Anaesthesiology and Critical Care, Pitié-Salpêtrière Hospital, Paris, France;2. Université de Nantes, CHU Nantes, Pôle Anesthésie Réanimations, Service d''Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, France;3. Sorbonne University-INSERM UMRS_959, Immunology-Immunopathology-Immunotherapy (I3), 75013 Paris, France;1. Hôpital Béclère, Clamart, France;2. Hospices civils de Lyon, Lyon, France;3. Hospices civils de Strasbourg, Strasbourg, France;4. CHU de Lille, Lille, France;5. CHU de Caen, Caen, France;6. Hôpital Cochin, APHP, Paris, France;7. CH de Perpignan, Perpignan, France;8. CHU de Tours, Tours, France;9. CHU de Nantes, Nantes, France;10. CH de Narbonne, Narbonne, France;11. CHU de Dijon, Dijon, France;12. CHU de Saint Etienne, Saint-Etienne, France;13. CH de la Cote Basque, Bayonne, France;14. CHU de Nantes, Nantes, France;15. Hôpital Saint Joseph, Paris, France;16. Hôpital Saint Joseph, Paris, France;17. CH de Versailles, Versailles, France;18. CH de Saint Brieuc, Saint Brieuc, France;19. CHU de Nantes, Nantes, France;20. Hôpital Cochin, APHP, Paris, France;21. Ch de Libourne, Libourne, France;22. CH de Périgueux, Périgueux, France;23. CHU de Bordeaux, Bordeaux, France;24. CHU de Saint Etienne, Saint-Etienne, France;25. CHU de Dijon, Dijon, France;26. CHU de Besançon, Besançon, France;27. CH Alpes Léman, Annemasse, France;28. CHU de Nice, Nice, France;29. CH Delafontaine, Saint-Denis (93), France;30. CH Delafontaine, Saint-Denis (93), France;31. CHU de Caen, Caen, France;32. CH Delafontaine, Saint-Denis (93), France;33. CHU de Limoges, Limoges, France;34. CHU de Nantes, Nantes, France;35. CHU Raymond Poincarré, Garches, France;36. CHU de Grenoble, France;37. CH de Saint Brieuc, Saint Brieuc, France;38. CH de Chambéry, Chambéry, France;39. CH d''Alès, Alès, France;40. CHU de Nantes, Nantes, France;41. CHU de Saint Etienne, Saint-Etienne, France;42. CHU de Montpellier, Montpellier, France;43. CH de Quncy sous Sénart, Quincy sous Sénart, France;44. Hôpital Bichat, Paris, France;45. CHU de Nancy, Nancy, France;46. CHU de Caen, Caen, France;47. CH de Colmar, Colmar, France;48. CH de Colmar, Colmar, France;49. CHU de Rouen, Rouen, France;50. CH de Vendée, La Roche sur Yon, France;51. CH Delafontaine, Saint-Denis (93), France;52. CHJU de Reims, Reims, France;53. Hôpital Cochin, APHP, Paris, France;54. Hôpital Saint Joseph, Paris, France;55. CH de Perpignan, Perpignan, France;56. CHU Cochin, Paris, France;57. CHU de Nantes, Nantes, France;58. CHU de Grenoble, Grenoble, France;59. CHU de Poitiers, Poitiers, France;60. CHU de Nantes, Nantes, France;61. CHU de Nantes, Nantes, France;62. CHU de Nantes, Nantes, France;63. CH d''Annecy-Genevois, Annecy, France;64. CHU Bichat, Paris, France;65. CH de la Rochelle, La Rochelle, France;66. Hôpital Foch, Suresnes, France;67. CH de Metz, Metz, France;68. CHU d''Angers, Angers, France;69. CHU de Montpellier, Montpellier, France;70. CH de Saint-Nazaire, Saint-Nazaire, France;71. CHU de Montpellier, Montpellier, France;72. CHU Cochin, Paris, France;73. CHU de Toulouse, Toulouse, France;74. CH de Colmar, Colmar, France;75. CHU de Montpellier, Montpellier, France;76. CH Manchester, Charleville-Mézières, France;77. CHU Raymond Poincarré, Garches, France;78. CH d''Aix, Aix-en-Provence, France;79. CHU Avicennes, Bobigny, France;80. CHU de Lille, Lille, France;81. CHU de Nantes, Nantes, France;82. CH de Colmar, Colmar, France;83. CHU de Montpellier, Montpellier, France;84. CHU de Rennes, Rennes, France;85. CHU de Grenoble, Grenoble, France;86. CH de Vendée, La Roche sur Yon, France;87. CHU de Martinique, Fort-de-France, France;88. CHU de Grenoble, Grenoble, France;89. CH Annecy-Genevois, Annecy, France;90. Hôpital Saint-Louis, Paris, France;91. Hôpital Salpétrière, Paris, France;92. CHU de Bordeaux, Bordeaux, France;93. CHU de Nantes, Nantes, France;94. CH du Havre, Le Havre, France;95. Hospices civils de Lyon, Lyon, France;96. Hospices civils de Lyon, Lyon, France;97. Hôpital Saint Joseph, Paris, France;98. CHU de Strasbourg, Strasbourg, France;99. CHR d''Orléans, Orléans, France;100. Hôpital Laveran, Marseille, France;101. Hôpital Bichat, Paris, France;102. CHU de Grenoble Alpes, Grenoble, France;103. CHU de Rennes, Rennes, France;104. CHU de Fort de France, Fort de France, France;105. CHU de Nancy, Nancy, France;106. CH de la Cote Basque, Bayonne, France;107. CHU de Clermont-Ferrand, Clermont-Ferrand, France;108. CH Annecy-Genevois, Annecy, France;109. Hôpital Foch, Suresnes, France;110. CH de la Cote Basque, Bayonne, France;111. Hôpital Saint Joseph, Paris, France;112. CH d''Aix en Provence, Aix en Provence, France;113. Hôpital Delafontaine, Saint-Denis (93), France;114. Ch de Versailles, Versailles, France;115. CH de Périgueux, Périgueux, France;116. CHU de Limoges, Limoges, France;117. CHU Grenoble Alpes, Grenoble, France;118. Hôpital Raymond Poincarré, Garches, France;119. Hospices civils de Lyon, Lyon, France;120. Santé publique France, Saint-Maurice, France;121. CHU Grenoble Alpes, Grenoble, France;122. CHU de Poitiers, Poitiers, France;123. CHU Grenoble Alpes, Grenoble, France;124. Hôpital Bichat, Paris, France;125. CHU de Rennes, Rennes, France;1. Intensive care unit, Centre Hospitalier Yves Le Foll, Saint Brieuc, France;2. INSERM, CIC 1414, Rennes, France;3. Santé Publique France, Saint-Maurice, France;4. University Grenoble Alpes, Infectious diseases department, Grenoble, France;5. Infectious diseases department, CHU Ponchaillou, Rennes, France;1. Guy''s and St Thomas'' NHS Foundation Trust, St Thomas'' Hospital, London SE1 7EH, UK;2. Centre of Human Applied Physiological Sciences, King''s College London, London, UK;3. Department of Anesthesiology, University Medical Center of Göttingen, Germany;4. Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King''s College London, London, UK;5. Department of Anesthesiology and Intensive Care, ASST Santi e Paolo Hospital, University of Milan, Italy |
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| Abstract: | RationaleSepsis is a syndrome of life-threatening organ dysfunction caused by a dysregulated host immune response to infection. Social risk factors including location and poverty are associated with sepsis-related disparities. Understanding the social and biological phenotypes linked with the incidence of sepsis is warranted to identify the most at-risk populations. We aim to examine how factors in disadvantage influence health disparities related to sepsis.MethodsA scoping review was performed for English-language articles published in the United States from 1990 to 2022 on PubMed, Web of Science, and Scopus. Of the 2064 articles found, 139 met eligibility criteria and were included for review.ResultsThere is consistency across the literature of disproportionately higher rates of sepsis incidence, mortality, readmissions, and associated complications, in neighborhoods with socioeconomic disadvantage and significant poverty. Chronic arterial hypertension and diabetes mellitus also occur more frequently in the same geographic distribution as sepsis, suggesting a potential shared pathophysiology.ConclusionsThe distribution of chronic arterial hypertension, diabetes mellitus, social risk factors associated with socioeconomic disadvantage, and sepsis incidence, are clustered in specific geographical areas and linked by endothelial dysfunction. Such population factors can be utilized to create equitable interventions aimed at mitigating sepsis incidence and sepsis-related disparities. |
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