A method for the preparation of [13C6]‐labelled 2‐substituted naphthalenes |
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| Authors: | George J Ellames John M Herbert |
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| Affiliation: | Isotope Chemistry and Metabolite Synthesis Department, Sanofi‐Aventis, Willowburn Avenue, Alnwick, Northumberland NE66 2JH, UK |
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| Abstract: | A reliable route is described for the preparation of various 2‐substituted derivatives of 1,2,3,4,4a,8a‐13C6]‐naphthalene via the bromide 10. The approach is used to prepare naphthalene‐1,2,3,4,4a,8a‐13C6]‐2‐(2‐bromoethyl)naphthalene (1), a key intermediate in the synthesis of labelled SR57746A, Xaliproden (2). Copyright © 2010 John Wiley & Sons, Ltd. |
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| Keywords: | 13C [13C6]‐naphthalene [13C6]‐2‐bromonaphthalene [13C6]‐SR57746A benzannulation 7‐bromo‐1‐[4a 5 6 7 8 8a‐13C6]tetralone |
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