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| GIK对急性缺血/再灌注犬心肌损伤的影响 | |
| 引用本文： | 何蓉,姚德厚,贾小兵,陈璇,李丹,李源.GIK对急性缺血/再灌注犬心肌损伤的影响[J].西南国防医药,2011,21(5):485-487. |
| 作者姓名： | 何蓉 姚德厚 贾小兵 陈璇 李丹 李源 |
| 作者单位： | 1. 成都军区机关医院内三科,成都,610011 2. 成都军区疾病预防控制中心 3. 大连市中心医院心内科 4. 第四军医大学西京医院老年病科 |
| 摘 要： | 目的比较GIK（葡萄糖-胰岛素-钾）和GK（葡萄糖-钾）对犬在体急性心肌缺血/再灌注（MI/R）血液流变性和心肌损伤的影响,讨论胰岛素在GIK保护心肌缺血中的作用。方法采用定量缺血的方法制备犬急性MI/R模型,再灌注GIK、GK或生理盐水4 h后,抽取冠状静脉窦血,比较各组的红细胞压积（HCT）、全血高切粘度（ηbh）、全血低切粘度（ηbl）、血浆乳酸脱氢酶（LDH）、肌酸激酶CK）和梗死区面积的变化。结果 GIK组与另两组相比,再灌注后ηbh、ηbl、TK、HCT均有明显的改变（P〈0.05）。GIK明显降低心肌梗死后LDH和CK活性（P〈0.05）,心肌梗死范围减少（P〈0.05）。结论 GIK可改善MI/R犬血液流变学特性,降低全血黏度;减轻心肌损伤,显著地缩小急性心肌梗死范围,并减轻梗死程度,胰岛素是GIK中的关键成分。 |
| 关 键 词： | GIK 胰岛素 血液流变性 缺血/再灌注损伤 心肌 |
Effects of glucose-insulin-potassium on myocardial injury after ischemia/reperfusion in dogs |
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| He Rong,Yao Dehou,Jia Xiaobing,Chen Xuan,Li Dan,Li Yuan.Effects of glucose-insulin-potassium on myocardial injury after ischemia/reperfusion in dogs[J].Medical Journal of National Defending forces in Southwest China,2011,21(5):485-487. | |
| Authors: | He Rong Yao Dehou Jia Xiaobing Chen Xuan Li Dan Li Yuan |
| Affiliation: | He Rong1,Yao Dehou1,Jia Xiaobing1,Chen Xuan2,Li Dan3,Li Yuan4 1.Third Department of Internal Medicine,Institution Hospital of Chengdu Military Command,Chengdu,Sichuan,610011,China,2.Center for Disease Control and Prevention of Chengdu Military Command,610021,3.Department of Cardiology,Central Hospital of Dalian City,Dalian,Liaoning,116033,4.Department of Gerontology,Xijing Hospital of Fourth Military Medical University,Xi'an,Shanxi,710032 |
| Abstract: | Objective To compare the effects of glucose-insulin-potassium(GIK)and glucose-potassium(GK)on hemorheological characteristics and myocardial injury after ischemia/perfusion in dogs in vivo,and to discuss the role of insulin in protecting ischemic myocardium.Methods Acute myocardial ischemia/perfusion(I/R)model of canine in vivo were prepared following a 50 min ischemia and 4 h reperfusion.They were treated with 0.9% normal saline,GIK(glucose: 50 g/L,insulin: 60 U/L,potassium: 80 mmol/L)and GK(glucose: 250 g... |
| Keywords: | GIK |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
