Effects of conjugated linoleic acid isomers on the hepatic microsomal desaturation activities in vitro |
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Authors: | L Bretillon J M Chardigny S Grégoire O Berdeaux J L Sébédio |
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Affiliation: | (1) Unité de Nutrition Lipidique, INRA, 17 rue Sully, BP 1540, F-21034 Dijon Cedex, France |
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Abstract: | The influence of individual conjugated linoleic acid (CLA) isomers on the Δ6 desaturation of linoleic and α-linolenic acids
and on the Δ9 desaturation of stearic acid was investigated in vitro, using rat liver microsomes. The Δ6 desaturation of 18∶2n−6 was decreased from 23 to 38% when the ratio of 9cis,11trans-18∶2 to 18∶2n−6 increased from 0.5 to 2. The compound 10trans,12cis-18∶2 exhibited a similar effect only at the highest concentration. The Δ6 desaturation of α-linolenic acid was slightly affected
by the presence of CLA isomers. The sole isomer to induce an inhibitory effect on the Δ9 desaturation of stearic acid was
10trans,12cis-18∶2. |
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