Colorectal cancer carcinogenesis: From bench to bedside |
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Authors: | Pedro Currais Isadora Rosa Isabel Claro |
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Affiliation: | Pedro Currais, Isadora Rosa, Isabel Claro, Department of Gastroenterology, Instituto Portugues de Oncologia de Lisboa Francisco Gentil, Lisboa 1099-023, Portugal |
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Abstract: | Colorectal cancer (CRC) remains one of the main causes of cancer death in developed countries. Yet, it is potentially preventable, by removing the precursor lesions - adenomas or serrated lesions. Several studies proved that this intervention reduces CRC mortality and that the first colonoscopy’s results can guide surveillance strategies. More recently, it became clear that several carcinogenesis pathways may lead to sporadic CRC. CRC is a heterogeneous disease, characterized by multiple molecular subtypes. Three main pathways have been implicated in the development of CRC: Chromosomal instability, microsatellite instability, and the “serrated” pathways, with overlapping features between them. This and other molecular and genetic based CRC classifications are known to have clinical implications, spanning from familial risk assessment to therapy choices. The authors review basic science data and provide insight on current implications for the management of patients with CRC. |
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Keywords: | Colorectal cancer Carcinogenesis pathways Microsatellite instability APC KRAS BRAF |
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| 点击此处可从《World journal of gastrointestinal oncology》浏览原始摘要信息 |
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