蚊香对小鼠血清ALT、AST、TBIL及肝组织的影响

目的观察蚊香对小鼠血清丙氨酸氨基转移酶（ALT）和天门冬氨酸氨基转移酶（AST）、总胆红素（TB IL）及肝组织的影响。方法将60只小鼠随机分为4组,每组15只。慢性吸入组每天熏蚊香8 h,连续6 d;急性吸入组急熏蚊香3 h;联合吸入组在慢性吸入的基础上再急熏3 h;空白组不作处理。各组小鼠处理后立刻检测血清中ALT、AST和TB IL的含量并观察肝组织的病理切片。结果联合吸入组的血清ALT和AST均明显高于其他组（P〈0.01）,慢性吸入组的血清ALT和AST亦明显高于急性吸入组和空白对照组（P〈0.01）;联合吸入组、慢性吸入组的血清TB IL明显高于急性吸入组和对照组（P〈0.01）。病理切片显示联合吸入组、慢性吸入组、急性吸入组的肝组织均有不同程度的水变性和肝窦充血。结论蚊香对小鼠肝脏具有损害作用。

Effect of Mosquito-repellent Incense on Serum ALT,AST,TBIL and Liver Tissues of Mice

Objective To study the effect of serum alanine aminotrausferase （ALT）, aspartate aminotransferase （AST）, total bilirubin （TBIL） and liver tissue on mice by mosqulto-repellent incense. Methods 60 mice were divided randomly into 4 groups with each group of 15 mice. Mice in chronic inhalation group were smoked 8 hours everyday by mosquito-repellent incense for 6 days;mice in acute inhalation group were smoked by mosquito-repeUent incense for 3 hours;the operation of joint inhalation group were combined the operation of chronic inhalation group and acute inhalation group;no operation was given to mice in blank group. Every mouse was detected the serum content of ALT,AST and TBIL right after operation and observed the pathological changes of liver tissues. Results rFne serum contents of ALT and AST in joint inhalation group were higher than those other groups （P 〈0.01 ）. The serum content of ALT and AST in chronic inhalation group were higher than of acute inhalation group and the blank group （P 〈0.01 ） ;the serum content of TBIL in joint inhalation group and chronic inhalation group were higher than those of acute inhalation group and the blank group （P 〈0. 01 ）;the pathological changes of liver tissues showed that there was varying degrees hydropic degeneration of liver and hyperaemia in hepatic sinus. Conclusion Mosquito-repellent incense is harmful to the liver in mice.