| 单链抗体及其融合蛋白在肿瘤诊治中的应用 |
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| 引用本文： | 唐彩华,刘长征.单链抗体及其融合蛋白在肿瘤诊治中的应用[J].中国肿瘤,2004,13(3):167-170. |
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| 作者姓名： | 唐彩华 刘长征 |
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| 作者单位： | 中山大学基础医学院实验核医学教研室,广东,广州,510080 |
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| 摘 要： | 单链抗体由于分子量小,免疫原性低,组织穿透力强,特异性好等优点,与单克隆抗体相比,在肿瘤的诊断和治疗方面展示了更好的应用前景.全文对近年来单链抗体及其融合蛋白在肿瘤导向诊断和治疗,肿瘤基因治疗和肿瘤疫苗方面应用研究进展做一综述.
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| 关 键 词： | 单链抗体 融合蛋白 肿瘤 治疗 |
| 文章编号： | 1004-0242(2004)03-0167-04 |
Application of Recombinant Single-chain Antibody and Its Fusion Protein to Diagnosis and Treatment for Cancer |
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| TANG Cai-hua,LIU Chang-zheng.Application of Recombinant Single-chain Antibody and Its Fusion Protein to Diagnosis and Treatment for Cancer[J].Bulletin of Chinese Cancer,2004,13(3):167-170. |
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| Authors: | TANG Cai-hua LIU Chang-zheng |
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| Abstract: | Single-chain antibody is superior to monoclonal antibody in tumor diagnosis and treatment,because of their small molecular weights,low immunogenicity,strong tissues penetration force,and good specific binding capacity with tumor.The advances of single-chain antibody and their fusion protein used in tumor targeting diagnosis and therapy,gene therapy,and cancer vaccine in recent years were reviewed. |
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| Keywords: | single-chain antibody fusion protein neoplasm treatment |
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