基于活性碳纤维的三柱反式选择型99Mo-99Tcm发生器

世界范围内医用⁹⁹Tc^m供应链仍很脆弱，开发基于非裂变产物⁹⁹Mo的⁹⁹Mo-⁹⁹Tc^m分离装置及工艺对于提高我国99Tcm供应能力十分重要。活性碳纤维（ACF）是性能优良的钼锝色层分离材料，可用于制备多柱选择性反向发生器（MSIG）结构的非裂变⁹⁹Mo-⁹⁹Tc^m色层发生器。基于ACF改性和评价工作，利用重新设计的全自动非裂变⁹⁹Mo-⁹⁹Tc^m发生器装置，开发三柱⁹⁹Mo-⁹⁹Tc^m分离纯化工艺，并用该装置分离纯化获得的高锝［⁹⁹Tc^m］酸钠注射液进行MDP、MIBI药盒的标记。结果表明，非裂变⁹⁹Mo-⁹⁹Tc^m发生器三柱分离工艺对⁹⁹Mo-⁹⁹Tc^m模拟液中⁹⁹Tc^m收率可达78%，得到的高锝［⁹⁹Tc^m］酸钠注射液放化纯度和MDP、MIBI药盒标记率均符合《中国药典》要求。基于活性碳纤维开发的三柱反式选择型⁹⁹Mo-⁹⁹Tc^m发生器有望用于从非裂变⁹⁹Mo中提取⁹⁹Tc^m。

Activated Carbon Fiber as Matrix for Three-Column Selectivity Inversion99Mo-99TcmGenerator

The supply chain of medical⁹⁹Tc^min the world is still very fragile,so the development of⁹⁹Mo-⁹⁹Tc^mseparation devices and processes based on non-fission⁹⁹Mo is very important to improve the security of⁹⁹Tc^msupply in China.Activated carbon fiber(ACF)is a molybdenum technetium chromatographic separation material with excellent performance,which can be used to prepare non-fission⁹⁹Mo-⁹⁹Tc^mchromatographic generator with multi-column selective reverse generator(MSIG)structure.Based on the modification and evaluation of ACF,a three-column⁹⁹Mo-⁹⁹Tc^mseparation and purification process was developed by using an automatic non-fission⁹⁹Mo-⁹⁹Tc^mgenerator,and the sodium pertechnetate⁹⁹Tc^m]injection obtained by this device was used to label MDP and MIBI kits.The yield of⁹⁹Tc^min⁹⁹Mo-⁹⁹Tc^msimulated solution by non-fission⁹⁹Mo-⁹⁹Tc^mgenerator three-column separation process was 78%.The resulting sodium pertechnetate⁹⁹Tc^m]injection,radiochemical purity and labeling rate of MDP and MIBI kits all met the requirements of Chinese Pharmacopoeia.The three-column selectivity inversion⁹⁹Mo-⁹⁹Tc^mgenerator based on ACF is expected to be used to extract⁹⁹Tc^mfrom non-fission⁹⁹Mo.