| 胃和结直肠腺癌患者血清RASSF1A基因启动子异常甲基化检测及其临床意义 |
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| 引用本文： | 于正洪,史兆荣,高勇,王玉才,苏全胜,郁红菊,刘畅,林勇,马驰原.胃和结直肠腺癌患者血清RASSF1A基因启动子异常甲基化检测及其临床意义[J].癌症进展,2011,0(5):555-560,554. |
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| 作者姓名： | 于正洪 史兆荣 高勇 王玉才 苏全胜 郁红菊 刘畅 林勇 马驰原 |
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| 作者单位： | 南京军区南京总医院肿瘤内科,南京,210002;南京军区南京总医院干部保健科,南京,210002;南京军区南京总医院普通外科,南京,210002;南京军区南京总医院博士后科研工作站,南京,210002 |
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| 基金项目： | 江苏省六大人才高峰重点课题基金资助项目(批准号:2005A2); 南京军区南京总医院科研课题(批准号:2009M033) |
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| 摘 要： | 目的 研究胃和结直肠腺癌患者血清RASSF1A基因启动子区域的甲基化状态及其临床意义.方法采用甲基化特异性聚合酶链反应(MSP)技术,检测47例胃腺癌患者、45例结直肠腺癌患者、60例胃肠道良性病变患者及30例健康志愿者血清RASSF1A基因启动子区域的甲基化状态,并同时检测25例进行手术的胃腺癌、结直肠腺癌患者的肿瘤...
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| 关 键 词： | 胃癌 结直肠癌 RASSF1A基因 DNA甲基化 |
RASSF1A promoter hypermethylation of serum DNA in gastric and colorectal adenocarcinoma patients |
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| Yu Zhenghong Shi Zhaorong Gao Yong Wang Yucai Su Quansheng Yu Hongju Liu Chang Lin Yong Ma Chiyuan.RASSF1A promoter hypermethylation of serum DNA in gastric and colorectal adenocarcinoma patients[J].Oncology Progress,2011,0(5):555-560,554. |
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| Authors: | Yu Zhenghong Shi Zhaorong Gao Yong Wang Yucai Su Quansheng Yu Hongju Liu Chang Lin Yong Ma Chiyuan |
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| Affiliation: | Yu Zhenghong1 Shi Zhaorong2 Gao Yong3 Wang Yucai1 Su Quansheng1 Yu Hongju1 Liu Chang1 Lin Yong1 Ma Chiyuan4Department of Oncology,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,China |
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| Abstract: | Objective To detect the hypermethylation of RASSF1A promoter in serum DNA of the gastric and colorectal adenocarcinoma patients and to analyze its correlation with clinicopathological features.Methods Serum DNA was extracted from peripheral blood of 47 primary gastric adenocarcinoma patients,45 primary colorectal adenocarcinoma patients,60 benign gastrointestinal disease patients and 30 healthy donors.In 25 gastric and colorectal adenocarcinoma patients who later underwent surgical therapy,promoter methylat... |
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| Keywords: | gastric cancer colorectal cancer RASSF1A DNA methylation |
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