The effect of bacterial melanin on electrical activity of neurons of the substantia nigra under conditions of GABA generation |
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| Authors: | J S Sarkissian A A Galoyan R G Kamalyan V A Chavushyan I B Meliksetyan M V Poghosyan O V Gevorkyan A S Hovsepyan Z E Avakyan S A Kazaryan M K Manucharyan |
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| Affiliation: | (1) Orbeli Instute of Physiology, National Academy of Sciences of Republic of Armenia, ul. Br. Orbeli 22, Yerevan, 0028, Republic of Armenia;(2) Buniatyan Institute of Biochemistry, National Academy of Sciences of Republic of Armenia, Yerevan, Republic of Armenia;(3) Scientific Institute of Biotechnology, Yerevan, Republic of Armenia;(4) Mnjoyan Institute of Fine Organic Chemistry, National Academy of Sciences of Republic of Armenia, Yerevan, Republic of Armenia |
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| Abstract: | The changes in spike activity of single neurons of the compact part of the substantia nigra, evoked by nucleus caudatus stimulation under conditions of long-term registration of the single and multiple, isolated and combined actions of GABA, GABA-amide, glutamine, and ethanolamine-O-sulfate (EOS) were studied in albino rats. Inhibition of poststimulus activity under GABA action was recorded and the inhibitory effect of GABA-amide was revealed. Primary excitatory and subsequent inhibitory effects of glutamine in combination with EOS were shown. The subsequent administration of bacterial melanin, synthesized by a mutant culture of Bacillus thuringiensis (BT-M) evoked a clear-cut and prolonged excitatory reaction during all the combined actions of GABA, GABA-amide, glutamine, and EOS. Preliminary administration of BT-M abolished the inhibitory poststimulus effects of GABA, GABA-amide, and EOS, as well as glutamine-induced excitation. |
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| Keywords: | single neuronal activity substantia nigra nucleus caudatus bacterial melanin glutamine GABA GABA-amide ethanolamide-O-sulfate |
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