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风湿性心脏瓣膜病房颤肺静脉组织学及pgp9.5蛋白分布研究
作者单位:第二军医大学附属长海医院胸心外科
摘    要:目的:探讨风湿性心脏瓣膜病合并房颤病人肺静脉组织学及pgp9.5(product gene protein 9.5)蛋白表达的变化特点。方法:选取风湿性心脏瓣膜病行瓣膜置换术病人26例,术中收集右上肺静脉标本。将病人分为房颤心律组(n=14),窦性心律组(n=12),对肺静脉标本行HE染色及pgp9.5蛋白Envension免疫组织化学染色。结果:与窦性心律组相比,房颤组心肌袖部心肌细胞肥大,肌束间间隙较大,排列更紊乱;脂肪垫及心肌组织有大量表达pgp9.5蛋白的细胞。结论:风湿性心脏病合并房颤致肺静脉心肌袖部心肌细胞肥大,间隙增宽;免疫组化染色表明肺静脉组织有大量表达pgp9.5蛋白的细胞存在。

关 键 词:风湿性心脏瓣膜病  心房颤动  肺静脉  组织学  Pgp9.5蛋白

Histology and pgp9.5 protein distribution in the pulmonary vein tissues of patients with atrial fibrillation and rheumatic heart valve disease
ZHOU Yong,LI Li,XU Zhiyun,ZOU Liangjian,HAN lin,XU jibin,LU fanglin.Departmert of Cardiothoracic,Changhai Hospital of Second Military Medical University,Shanghai ,China.. Histology and pgp9.5 protein distribution in the pulmonary vein tissues of patients with atrial fibrillation and rheumatic heart valve disease[J]. , 2008, 0(5)
Authors:ZHOU Yong  LI Li  XU Zhiyun  ZOU Liangjian  HAN lin  XU jibin  LU fanglin.Departmert of Cardiothoracic  Changhai Hospital of Second Military Medical University  Shanghai   China.
Affiliation:ZHOU Yong,LI Li,XU Zhiyun,ZOU Liangjian,HAN lin,XU jibin,LU fanglin.Departmert of Cardiothoracic,Changhai Hospital of Second Military Medical University,Shanghai 200433,China.
Abstract:Objective:To explore histological features and distribution of pgp9.5 protein in the pulmonary veins(PVs) tissues from patients with permanent atrial fibrillation(pAF) and rheumatic heart valve disease.Methods:Twenty-six patients suffered from rheumatic valves diseases and underwent mitral(with or without aortic) valve replacement were enrolled and divided into two groups: AF group(14 patients with pAF) and control group(12 patients with sinus rhythm).Histological features and distribution of pgp9.5 protein in the specimens of the right superior pulmonary veins from two groups were assayed with HE staining and immunohistochemistry respectively.Results:Compared with the sinus rhythm group,PVs muscle cells from pAF group are more hypertrophic,and the arrangements of muscle bundles are broader.A lot of pgp9.5-expressing cells were found with positive staining in the PV muscle sleeves and the fat pads from both groups.Conclusion:The arrangements of myocardial bundles from patients with pAF are broader than those with sinus rhythm.A lot of pgp9.5-expressing cells are detected by immunohistochemistry in pulmonary veins tissues.
Keywords:Rheumatic heart valve disease  Atrial fibrillation  Pulmonary veins  Histology  Pgp9.5
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