| 党参及茯苓对小鼠肠道菌群调节作用的实验研究 |
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| 引用本文： | 宋克玉,江振友,严群超,陈深,施珊珊.党参及茯苓对小鼠肠道菌群调节作用的实验研究[J].中国临床药理学杂志,2011,27(2). |
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| 作者姓名： | 宋克玉 江振友 严群超 陈深 施珊珊 |
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| 作者单位： | 暨南大学医学院微生物学与免疫学系,广州,510632 |
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| 基金项目： | 国家自然科学基金资助项目(30973693) |
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| 摘 要： | 目的研究党参和茯苓(均为补益中药)对小鼠肠道菌群的影响。方法 BALB/C♂小鼠随分为7组:空白组、党参与茯苓的低、中、高剂量组,各组的受试药物灌胃浓度分别为人体推荐量的5,10,30倍,空白对照组用无菌水代替受试物。连续给药14天后,取肠道内容物,溶解涂布筛选平板,培养计数。以小鼠粪便中的双歧杆菌、乳杆菌、大肠杆菌和肠球菌数量为检测指标,观察给药后小鼠肠道菌群的变化。结果高剂量的党参能显著提高肠道乳杆菌水平并降低大肠杆菌水平;而高剂量的茯苓能显著提高肠道双歧杆菌的水平。结论党参和茯苓对肠道菌群都有较好的调节作用。
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| 关 键 词： | 党参 茯苓 肠道菌群 |
Experimental study on the effect of Radix codonopsis and Poria on intestinal flora in mice |
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| SONG Ke-YU,JIANG Zhen-you,YAN Qun-chao,CHEN Chen,SHI Shan-shan.Experimental study on the effect of Radix codonopsis and Poria on intestinal flora in mice[J].The Chinese Journal of Clinical Pharmacology,2011,27(2). |
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| Authors: | SONG Ke-YU JIANG Zhen-you YAN Qun-chao CHEN Chen SHI Shan-shan |
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| Affiliation: | SONG Ke-yu,JIANG Zhen-you,YAN Qun-chao,CHEN Chen,SHI Shan-shan(Department of Microbiology and Immunology,School of Medical,Jinan University,Guangzhou 510632,China) |
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| Abstract: | Objective To investigate the effect of Radix codonopsis and Poria on the intestinal microflora in mice.Method BALB /C white mice were divided into 7 groups: A blank control group and corresponding low,medial and high dose groups,the concentrations are 0,5,10,30-fold of people recommended dosage,respectively.After administrate intragastrically for 14 days,solution of the bowel contents were cultured on plate,coutting the bacterial colonies,to detect the amounts of Bifidobacterium,Lactobacillus,Escherichia co... |
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| Keywords: | Radix codonopsis Poria intestinal flora |
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