Regioselectivity in the ring opening of non-activated aziridines |
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Authors: | Stanković Sonja D'hooghe Matthias Catak Saron Eum Heesung Waroquier Michel Van Speybroeck Veronique De Kimpe Norbert Ha Hyun-Joon |
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Affiliation: | Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium. |
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Abstract: | In this critical review, the ring opening of non-activated 2-substituted aziridines via intermediate aziridinium salts will be dealt with. Emphasis will be put on the relationship between the observed regioselectivity and inherent structural features such as the nature of the C2 aziridine substituent and the nature of the electrophile and the nucleophile. This overview should allow chemists to gain insight into the factors governing the regioselectivity in aziridinium ring openings (81 references). |
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