| 绞股蓝总皂甙对氯化镉所致睾丸生殖细胞毒性的影响 |
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| 引用本文： | 杜琰琰,李少群,石同幸.绞股蓝总皂甙对氯化镉所致睾丸生殖细胞毒性的影响[J].现代预防医学,2002,29(1):7-8. |
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| 作者姓名： | 杜琰琰 李少群 石同幸 |
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| 作者单位： | 广州市卫生防疫站,510080 |
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| 摘 要： | 目的：观察绞股蓝总皂甙（GPS）对雄性小鼠染镉后对睾丸生殖细胞的保护作用。方法：预先灌服GPS200mg/kg／d，连续16d后，腹腔注入氯化镉（Cd)3mg/kg/d 5d，观察睾丸病理切片和精子畸形率。结果：预服GPS的小鼠染镉后，其精子畸形率 比单纯染镉组下降53．01％（P＜0．01）。睾丸病理切片单纯染镉组出现病理改变，与预服GPS组相比未见明显差别。表明GPS对Cd所致小鼠精子畸形率有较好的抑制作用。结论：GPS可用于防治Cd对生殖系统的损害作用。
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| 关 键 词： | 绞股蓝总皂甙 氯化镉 精子畸形 睾丸生殖细胞 保护作用 |
| 文章编号： | 1003-8507(2002)01-0007-02 |
| 修稿时间： | 2001年2月27日 |
THE INHIBITION OF GYPENSIDES ON SPERM SHAPE ABNORMALITY IN MICE INDUCED BY CADMIUM CHLORIDE. |
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| DU Yan yan,LI Shao qun,ShI Tong xing.Sanitary and Antiepidemic Station of Guangzhou City,..THE INHIBITION OF GYPENSIDES ON SPERM SHAPE ABNORMALITY IN MICE INDUCED BY CADMIUM CHLORIDE.[J].Modern Preventive Medicine,2002,29(1):7-8. |
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| Authors: | DU Yan yan LI Shao qun ShI Tong xingSanitary and Antiepidemic Station of Guangzhou City |
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| Affiliation: | DU Yan yan,LI Shao qun,ShI Tong xing.Sanitary and Antiepidemic Station of Guangzhou City,510080. |
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| Abstract: | Objective:To explore the inhibition of gypensides(GPS) on sperm shape abnormality in mice induced by cadmium chloride(CdCl 2).Methods:After having feed the GPS at dose of 200mg/kg for 16 days,exposed at dose of 3 mg/kg the CdCl 2 for 5 days.Results:Observing state of injure on testis and the rate of sperm shape abnormality was decreased percent 53 01%,between GPS+Cd group and only Cd group( P <0 01).The difference was no significant in state of injure in two group on testis.Conclusion:The study declared that the GPS could inhibit the rate of sperm shape abnormality in mice induced by CdCl 2. |
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| Keywords: | Gypensides(GPS) Cadmium Sperm shape abnormality |
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