| 阿魏酸钠抗溴苯实验性肝损害作用机制的探讨 |
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| 引用本文： | 吴东方.阿魏酸钠抗溴苯实验性肝损害作用机制的探讨[J].中国药学杂志,1995,30(10):597-599. |
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| 作者姓名： | 吴东方 |
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| 作者单位： | 湖北省人民医院药学部，湖北医科大学药理教研室 |
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| 摘 要： | 观察了溴苯（ＢＢ）肝损害时阿魏酸钠（ＳＦ）的有效作用。结果表明，ＢＢ肝损害时ＳＡＬＴ、肝匀浆ＭＤＡ及肝微粒体细胞色素Ｐ－４５０酶活性均增高，同时肝微粒体及线粒体膜流动性亦增高。ＳＦ１００ｍｇ／ｋｇ口服可明显降低ＢＢ所致上述各指标的增高，使肝版粒体及线粒体膜流动性恢复至正常，提示ＳＦ对ＢＢ肝损害有保护作用，其机制可能与抗脂质过氧化，稳定细胞膜及降低肝脏药物代谢酶活性有关。
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| 关 键 词： | 阿魏酸钠 溴苯 脂质过氧化 膜流动性 药物代谢酶 肝脏 |
| 收稿时间： | 1994-08-29; |
The effects of sodium ferulate on bromobenzene-induced liver injury in mice |
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| Wu Dongfang.The effects of sodium ferulate on bromobenzene-induced liver injury in mice[J].Chinese Pharmaceutical Journal,1995,30(10):597-599. |
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| Authors: | Wu Dongfang |
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| Affiliation: | Department Of Pharmacy,people’s Hospital of Huhei province,Wuhan 430060;1.Department of Pharmacology,Hubei Medical University,Wuhan 430071 |
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| Abstract: | The effects of sodium ferulate(SF)on bromobenzene(BB)-induced liver injury wereobserved in mice.SALT,liver homogenate MDA content,and microsomal cytochrome P-450 activ-ity significantly increased in BB-treated mice,The membrane fluidity of liver microsome and mito-chondria was also elevated.The enhancement of above indexes in BB-treated mice were decreasedafter SF 100 mg/kg pretreatment,and the membrane fluidity of liver microsome and mitochondriareturned to normal.The results indicated that SF alleviated BB-induced liver damage,and itsmechanism was related to inhibition of liver lipid peroxidation,stablization of membrane fluidityand decline of drug metabolizing enzyme. |
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| Keywords: | sodium ferulate bromobenzene lipid peroxidation membrane fluidity drugmetabolizing enzyme liver |
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