| 利用恒河婴猴模型对肠道病毒71型传播感染特征的生物学分析 |
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| 引用本文： | 王晶晶,李薇,赵红玲,刘龙丁,唐东红,杨丽仙,董承红,纳锐雄,王丽春,张莹,梁燕,廖芸,李琦涵.利用恒河婴猴模型对肠道病毒71型传播感染特征的生物学分析[J].微生物与感染,2011,6(3):133-138. |
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| 作者姓名： | 王晶晶 李薇 赵红玲 刘龙丁 唐东红 杨丽仙 董承红 纳锐雄 王丽春 张莹 梁燕 廖芸 李琦涵 |
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| 作者单位： | 1. 中国医学科学院/北京协和医学院医学生物学研究所,云南省重大传染病疫苗研发重点实验室,昆明,650118;昆明医学院,昆明,650032
2. 中国医学科学院/北京协和医学院医学生物学研究所,云南省重大传染病疫苗研发重点实验室,昆明,650118 |
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| 基金项目： | 国家科技重大专项项目，国家重点基础研究发展计划(973)项目 |
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| 摘 要： | 本文在前期工作基础上,进一步对肠道病毒71型(EV71)从恒河婴猴的感染个体向其他未感染个体传播的可能性及相关生物学特性做了初步分析.通过喷雾形式经呼吸道感染1~2月龄恒河婴猴(A组);在观察临床症状同时,于感染后第7天,取该组动物粪便处理后,将上清液以喷雾形式经呼吸道感染新的婴猴个体(B组),随后对该次代感染个体进行...
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| 关 键 词： | 肠道病毒71型 恒河猴 传播 感染 动物模型 |
Biological characteristics related to the transmission of enterovirus 71 in neonatal rhesus monkeys |
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| WANG Jing-Jing,LI Wei,ZHAO Hong-Ling,LIU Long-Ding,TANG Dong-Hong,YANG Li-Xian,DONG Cheng-Hong,NA Rui-Xiong,WANG Li-Chun,ZHANG Ying,LIANG Yan,LIAO Yun,LI Qi-Han.Biological characteristics related to the transmission of enterovirus 71 in neonatal rhesus monkeys[J].Journal of Microbes and Infection,2011,6(3):133-138. |
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| Authors: | WANG Jing-Jing LI Wei ZHAO Hong-Ling LIU Long-Ding TANG Dong-Hong YANG Li-Xian DONG Cheng-Hong NA Rui-Xiong WANG Li-Chun ZHANG Ying LIANG Yan LIAO Yun LI Qi-Han |
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| Affiliation: | WANG Jing-Jing1,2,LI Wei1,ZHAO Hong-Ling1,LIU Long-Ding1,TANG Dong-Hong1,YANG Li-Xian1,DONG Cheng-Hong1,NA Rui-Xiong1,WANG Li-Chun1,ZHANG Ying1,LIANG Yan1,LIAO Yun1,LI Qi-Han11.Institute of Medical Biology,Chinese Academy of Medicine Science and Peking Union Medical College,Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases,Kunming 650118,China,2.Kunming Medical University,Kunming 650032 |
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| Abstract: | Using an established animal model of enterovirus 71(EV71) infection,the risk of EV71 transmission from infected neonatal to uninfected rhesus monkeys was assessed.Two 1-2 month-old neonatal monkeys were infected with EV71 via nasal spray(Group A).At 7 days post-infection,two neonatal monkeys assigned to Group B were inoculated with extracts from the feces of monkeys from Group A,via the same route.Meanwhile,two neonatal monkeys were inoculated with fecal extracts via intravenous injection(control group).The... |
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| Keywords: | Enterovirus 71 Rhesus monkey Transmission Infection Animal model |
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