颈动脉粥样硬化程度与血小板活化的相关性分析

目的：研究血小板活化指标CD62p，CD63与颈动脉粥样硬化的关系，以评价血小板活化在颈动脉粥样硬化形成中的作用。方法：以B超检测颈动脉，按动脉粥样硬化程度将患者分为：颈动脉正常组（正常组）、颈动脉内中膜增厚组（增厚组）、稳定性斑块组、不稳定性斑块组共4组，且同时测定CD62p、CD63，并进行颈动脉弱样硬化评分与危险因素相关性分析。结果：CD62p：不稳定性斑块组较其余三组均增高，P＜0．05－0．01，稳定性斑块组较正常组增高（P＜0．01）。CD63：不稳定性斑块组较正常组、内中膜增厚组增高（P＜0．05），稳定性斑块组较正常组增高（P＜0．05）。经多元逐步回归分析显示颈动脉粥样硬化程度与CD62p呈显著正相关。结论：血小权活化是颈动脉粥样硬化的危险因素之一。

The Association Between Platelet Activity and Carotid Atherosclerosis

Objective To assess the relationship between platelet activity marker(CD62p,CD63) and carotid atherosclerosis(CAS) and evaluate the action of platelet activity on CAS. Methods One hundred and thirty two subjects were examined with carotid ultrasound and were classified into four groups according to the severity of CAS. The patients without CAS were allocated to normal carotid artery (CA) group; the patients with intimal medial thickness (IMT) thickened were allocated to IMT thickened group; the patients with stable carotid atherosclerotic plaque (CAP) to stable CAP group; and those with unstable carotid atherosclerotic plaque to unstable CAP group. CD62p, CD63 were measure by flow cytometry in all patients. Results The serum level of CD62p was higher in the unstable CAP group as compared with that of the other three groups ( P <0.05 0.01), and the level of CD62p in the stable CAP group was higher than that of the normal CA group ( P <0.01). The serum level of CD63 in the unstable CAP group was higher than that of the normal CA group and IMT thickened group ( P <0.05) and the level of CD63 in the stable CAP group was higher than that of the normal CA group ( P <0.05). The multivariate stepwise regression analysis showed positive correlation between CD62p and CAS. Conclusion Platelet activity is one of the risk factors of CAS.