广西百色地区肝病患者及受血者HCV感染现状调查

笔者应用ＥＬＩＳＡ法对广西百色地区１７９例各类肝病患者及４１例受血者血清进行了抗－ＨＣＶ检测。结果各类肝病抗－ＨＣＶ阳性率为１７．９％，受血者抗－ＨＣＶ阳性率为３１．７％。在急性肝炎（急肝）、慢性肝炎（慢肝）、肝硬化和肝癌中，抗－ＨＣＶ阳性率各为４．３％（１／２３）、１２．８％（１０／７８）、２８．６％（１２／４２）和２５．０％（９／３６）。抗－ＨＣＶ阳性率有随肝病慢性比而增高的趋势，肝硬化的抗－ＨＣＶ阳性率明显高于急肝或慢肝（Ｐ＜０．０５），而肝癌的抗－ＨＣＶ阳性率与急肝或慢肝相差不显著（Ｐ＞０．０５或０．１），且发现ＨＢｓＡｇ阴性肝病者的抗－ＨＣＶ阳性率明显高于ＨＢｓＡｇ阳性患者（Ｐ＜０．５），肝病患者抗－ＨＣＶ的检出率与ＡＬＴ活性无关（Ｐ＞０．０５）。在受血者中，抗－ＨＣＶ的检出率与受血次数、ＡＬＴ活性关系非常密切。因此，加强对ＨＣＶ的检测是当前预防输血后肝炎的紧迫任务。

An Investigation on the Present Situation of HCV Infection Patients with Liver Diseases and in Blood Recipients in Baise District of Guang Xi

LISA was used to detect anti-HCV anti-body in 179 serum samples of patients with various types of liver diseases and 41 serum samples of blood recipients in Baise district of Guang Xi.The results showed that 17.9 % of patients with variotis types of liver diseases and 31.7% of blood recipients were anti-HCV positive.Among patients with liver diseases,the anti-HCV positive rate was 4.3%(1/23)in acute hepatitis(AH),12.8%(10/78)in chro-nic hepatitis (CH), 28.6%(12/42)in livercirrhosis(LC)and 25.0%(9/36)in hepatocellu-lar carcinoma(HCC).As liver diseases becamechronic, the anti-HCV positive rate tended torise.The anti-HCV positive rate in LC wassignificantly higher than that in AH or CH(P <0.05).The anti-HCV positive rate in HCC was not significantly different from that in AH or CH(P>0.05 or 0.1).It was found that the anti-HCV positive rate in HBsAg-negative patients was significantly higherthan that in HBsAg-positive patients(p<0.05).The anti-HCV positive rate in liverdiseases was not related to ALT ( P>0.05).In blood recipients,the anti-HCV positive rate was closely related to the number of transfusionand the activity of ALT.