Nobiletin alleviates high-fat diet-induced nonalcoholic fatty liver disease by modulating AdipoR1 and gp91phox expression in rats |
| |
| Affiliation: | 1. Faculty of Medicine, Mahasarakham University, Maha Sarakham, Thailand;2. Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;3. Cardiovascular Research Group, Khon Kaen University, Khon Kaen, Thailand;1. PhyMedExp, Université Montpellier, INSERM, CNRS, France;2. Research Center on Aging, affiliated with CIUSSS de l’Estrie-CHUS, 1036, rue Belvédère sud, Sherbrooke (Qc), Canada. J1H 4C4;3. University of Sherbrooke, Faculty of Physical Activity Sciences, 2500, boul. de l’Université, Sherbrooke (Qc), Canada. J1K 2R1;1. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China;2. Department of Cardiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 43000, Hubei Province, China;3. Cardiovascular Research Institute, Wuhan University, Wuhan 430060, China;4. Hubei Key Laboratory of Cardiology, Wuhan 430060, China;1. Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand;2. Faculty of Medicine, Mahasarakham University, Mahasarakham 44000, Thailand;3. Research Institute for Human High Performance and Health Promotion, Khon Kaen University, Khon Kaen 40002, Thailand |
| |
| Abstract: | Nobiletin, one of the polymethoxylated flavonoids isolated from citrus peels, is reported to possess various biological activities. The current study investigates the effect and possible mechanisms of nobiletin on nonalcoholic fatty liver disease (NAFLD) in high-fat diet (HFD)-fed rats. Male Sprague-Dawley rats were administrated with HFD and fructose (15%) in drinking water for 16 weeks to induce NAFLD. HFD-fed rats were treated with nobiletin (20 or 40 mg/kg/day) or vehicle for the last 4 weeks. Treatment of HFD-fed rats with nobiletin significantly reduced systolic blood pressure, adiposity, hyperlipidemia, insulin resistance, hepatic lipids content, NAFLD activity score and liver fibrosis. Nobiletin significantly increased plasma adiponectin levels, together with up-regulation of liver adiponectin receptor 1 (AdipoR1) expression. Additionally, decreased malondialdehyde levels and increased superoxide dismutase activity in plasma and hepatic tissue, consistent with down-regulation of liver NADPH oxidase subunit gp91phox expression, were also observed after nobiletin treatment. Furthermore, high dose of nobiletin exhibited higher therapeutic effect as a compared to low dose. These findings suggest that nobiletin alleviates HFD-induced NAFLD and metabolic dysfunction in rats. There might be an association between the observed inhibitory effect of nobiletin on NAFLD and modulation of AdipoR1 and gp91phox. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
