| 高强度聚焦超声抗大鼠早孕的蜕膜细胞凋亡机制 |
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| 引用本文： | 郑蓉,李晓艳,吴大琼,王瑞玲,李洪发,王泽华.高强度聚焦超声抗大鼠早孕的蜕膜细胞凋亡机制[J].中国超声医学杂志,2006,22(11):810-812. |
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| 作者姓名： | 郑蓉 李晓艳 吴大琼 王瑞玲 李洪发 王泽华 |
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| 作者单位： | 430022,武汉市,华中科技大学同济医学院协和医院妇产科 |
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| 摘 要： | 目的探讨HIFU抗早孕蜕膜细胞凋亡的机制。
方法HIFU以10W／cm^2辐照孕8d大鼠子宫90S。TUNEL法与免疫组织化学法检测蜕膜细胞凋亡及bcl-2和bax蛋白表达。
结果辐照后蜕膜细胞凋亡率及bax／bcl-2比值均高于对照组（P〈0．05）。
结论HIFU诱导蜕膜细胞凋亡是其抗早孕机理之一，bax／bcl-2比值增高参与了蜕膜细胞凋亡调控。
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| 关 键 词： | 高强度聚焦超声 蜕膜细胞 凋亡 抗早孕 |
| 收稿时间： | 2006-03-13 |
| 修稿时间： | 2006-06-26 |
Anti-gestation Mechanism of High Intensity Focused Ultrasound in Rats: Decidua Cell Apoptosis |
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| Zheng Rong, Li Xiaoyan, Wu Daqiong, et al.Anti-gestation Mechanism of High Intensity Focused Ultrasound in Rats: Decidua Cell Apoptosis[J].Chinese Journal of Ultrasound in Medicine,2006,22(11):810-812. |
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| Authors: | Zheng Rong Li Xiaoyan Wu Daqiong |
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| Affiliation: | Gyn and Obs Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022 China |
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| Abstract: | Objective To study the probable mechanism of rat abortion induced by high intensity focused ultrasound (HIFU).Methods Rats with 8-day gestation were radiated with HIFU.The controlled group was established without radiation.Decidua cell apoptosis and the expressions of bcl-2 and bax were examined via TUNEL and immunohistochemical method.Results Decidua apoptosis rate of the experimental group was higher than that of the control group (P<0.05).The bax /bcl-2 was higher than that of the control group (P<0.05). Conclusions The decidua cell apoptosis induced by HIFU in rats might be associated with the bax and bcl-2,and may be one of the mechanisms of early anti-gestation. |
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| Keywords: | High intensity focused ultrasound Decidua cell Apoptosis Early anti-gestation |
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