| 经颅重频磁刺激增强大鼠大脑中动脉梗塞再灌注损伤后神经重塑 |
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| 引用本文： | 徐涛,邢岩,崔丽英.经颅重频磁刺激增强大鼠大脑中动脉梗塞再灌注损伤后神经重塑[J].基础医学与临床,2011,31(1):1-5. |
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| 作者姓名： | 徐涛 邢岩 崔丽英 |
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| 作者单位： | 中国医学科学院,北京协和医学院,北京协和医院神经内科,北京,100730 |
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| 基金项目： | 国家自然科学基金(30470617) |
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| 摘 要： | 目的 通过观察大鼠大脑中动脉缺血再灌注损伤后7 d,大鼠神经功能、生长相关蛋白-43(GAP-43)、突触素(SYN)表达的变化,探讨经颅重频磁刺激(rTMS)对缺血性损伤后脑组织可塑性的影响.方法 制作大鼠右侧大脑中动脉梗塞再灌注模型,连续7 d给予不同频率和强度的rTMS,同时设立假刺激组和假手术组进行对照.观察大...
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| 关 键 词： | 经颅重频磁刺激 可塑性 生长相关蛋白-43 突触素 |
Effect of repetitive transcranial agnetic stimulation on the brain plasticity of rats after middle cerebral artery occlusion reperfusion injury |
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| XU Tao,XING Yan,CUI Li-ying.Effect of repetitive transcranial agnetic stimulation on the brain plasticity of rats after middle cerebral artery occlusion reperfusion injury[J].Basic Medical Sciences and Clinics,2011,31(1):1-5. |
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| Authors: | XU Tao XING Yan CUI Li-ying |
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| Affiliation: | XU Tao,XING Yan,CUI Li-ying(Dept.of Neurology,PUMC Hospital,CAMS & PUMC,Beijing 100730,China) |
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| Abstract: | Objective To explore the effect of rTMS on the plasticity of the brain after ischemic injury.MethodsSD rat MCAO-reperfusion model was established and then divided into four groups.Different rTMS were applied within 7 days after the reperfusion.The neurological impairment evaluation score of rats were recorded during this period.Immunohistochemistry and Western blot techniques were used to detect GAP-43 and SYN protein expressions.Results rTMS improved rehabilitation of neurofunction.rTMS increased the prote... |
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| Keywords: | repetitive transcranial magnetic stimulation plasticity growth associated protein-43(GAP-43) synaptophysin(SYN) |
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