西藏高原地区正常早孕期孕妇子宫动脉血流变化研究

目的比较不同海拔地区早孕期妊娠女性子宫动脉血流频谱特征。 方法前瞻性纳入2019年6月至2020年1月在西藏自治区人民医院及北京协和医院两个不同海拔地区进行常规产前检查的孕妇共144名，于孕11⁺⁰~13⁺⁶周行子宫动脉多普勒频谱测量。采用配对t检验比较左、右侧子宫动脉频谱测量数据差异；采用独立样本t检验比较不同海拔地区孕妇及高海拔地区不同民族孕妇的子宫动脉频谱测量参数的差异。 结果同一孕妇左、右侧子宫动脉多普勒参数比较，差异均无统计学意义（P均＞0.05）。43名高海拔地区孕妇与101名低海拔地区孕妇的双侧子宫动脉平均搏动指数（PI）分别为1.892±0.495和1.824±0.404，差异无统计学意义（P＞0.05）。高海拔地区28名藏族孕妇与15名汉族孕妇相比，双侧子宫动脉平均PI较高（2.016±0.521 vs 1.661±0.351），差异具有统计学意义（t=-2.366，P=0.023）。 结论不同海拔地区孕妇子宫动脉血流频谱特征无明显差异，但高海拔地区藏族孕妇双侧子宫动脉平均PI较高。子宫动脉血流频谱特征的影响因素，还需进一步研究以明确。

Doppler blood flow parameters of uterine arteries in women in first trimester of pregnancy in Tibet Plateau

ObjectiveTo compare the characteristics of uterine artery blood flow spectrum between early pregnant women at different altitudes. MethodsA total of 144 pregnant women at different altitudes who received routine prenatal examination at the People's Hospital of Tibet Autonomous Region and Peking Union Medical College Hospital from June 2019 to January 2020 were prospectively included. Uterine artery Doppler spectrum was measured at 11⁺⁰~13⁺⁶ weeks of pregnancy. Paired t-test was used to compare the spectrum of bilateral uterine arteries. Independent sample t-test was used to compare the parameters of the uterine artery in pregnant women at difference altitudes, and pregnant women of different ethnic groups in high altitudes. ResultsThere was no significant difference in Doppler parameters between the left and right uterine arteries in the same pregnant woman (P＞0.05). There was no significant difference in uterine artery pulsatility index (PI) between 43 pregnant women at a high altitude and 101 pregnant women at a low altitude (1.892±0.495 and 1.824±0.404, respectively, P＞0.05). In the high altitude area, the uterine artery PI of 28 Tibetan pregnant women (2.016±0.521) was higher than that of 15 Han pregnant women (1.661±0.351), the difference was statistically significant (t=-2.366, P=0.023). ConclusionThere is no significant difference in the spectral characteristics of uterine artery blood flow in pregnant women at different altitudes, but the average PI of bilateral uterine arteries in Tibetan pregnant women at a high altitude is higher. The influencing factors of uterine artery blood flow spectrum characteristics need to be further studied.