高内脏脂肪指数与高尿酸血症的相关性分析

  目的  探讨连云港市高血压人群内脏脂肪指数(visceral adiposity index, VAI)水平与新发高尿酸血症(hyperuricemia, HUA)的相关性，为HUA的早期预防以及疾病控制提供参考和依据。  方法  本研究来自中国脑卒中一级预防试验的尿酸子研究，共10 513名尿酸正常尿酸＜357 μmol/L (6 mg/dL)]的高血压患者纳入分析。本研究主要终点为新发HUA，定义为末次随访男性血尿酸浓度≥417 μmol/L(7 mg/dL)或女性血尿酸浓度≥357 μmol/L(6 mg/dL)。  结果  本研究共纳入了10 513例尿酸正常的高血压受试者。平均随访4.4年之后，共有1 642(15.6%)例受试者发生了HUA。分析结果显示，与VAI＜2.98(第一至三分位)的受试者相比，VAI≥2.98(第四分位)的受试者新发HUA的发生风险升高(13.8% vs. 21.1%；OR: 1.17；95% CI:1.01~1.36；P＜0.001)。此外，分层分析显示这种风险关系独立于组成VAI的四个指标(交互作用均有P＞0.05)。  结论  在连云港市的高血压人群中，VAI越大的人群患上HUA的风险越高。

Correlation analysis of high visceral adiposity index and hyperuricemia

  Objective  The relation between visceral adiposity index (VAI) and new-onset hyperuricemia remains largely understudied. This study seeks to further investigate the association between VAI and the risk of hyperuricemia by examining possible effect modifies in hypertensive patients.  Methods  A total of 10 513 hypertensive patients with normal uric acid (UA) concentrations < 357 μmol/L (6 mg/dL)] who participated the UA Sub-study of the China Stroke Primary Prevention Trial (CSPPT) were enrolled. Our primary outcome was new-onset hyperuricemia, which was defined as a UA concentration ≥417 μmol/L (7 mg/dL) in men or ≥357 μmol/L (6 mg/dL) in women at the exit visit.  Results  Over a median follow-up of 4.4 years, 1 642 (15.6%) participants developed new-onset hyperuricemia. When VAI was assessed as quartiles, a significantly higher risk of new-onset hyperuricemia was found in participants in quartile 4 (≥2.98; OR: 1.17; 95% CI: 1.01-1.36) compared with those in quartile 1-3 (< 2.98). Furthermore, the positive relation was independent of abnormal VAI components or numbers of abnormal VAI components (all P_interactions > 0.05).  Conclusions  There is a positive relationship between baseline VAI and the risk of new-onset hyperuricemia in a sample of Chinese hypertensive individuals.