| 油菜吲哚硫苷降解物对S180小鼠抗肿瘤作用的实验研究 |
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| 引用本文： | 文碧玲,李培武,李航森,赵力,余萍,邹俊清,张文,丁小霞,杨湄,汪雪芳,吴渝.油菜吲哚硫苷降解物对S180小鼠抗肿瘤作用的实验研究[J].中草药,2002,33(4):331-333. |
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| 作者姓名： | 文碧玲 李培武 李航森 赵力 余萍 邹俊清 张文 丁小霞 杨湄 汪雪芳 吴渝 |
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| 作者单位： | 1. 湖北中医学院附院,湖北武汉,430061
2. 中国农业科学院油料作物研究所,湖北武汉,430062 |
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| 基金项目： | 国家自然科学基金资助项目(39770452) |
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| 摘 要： | 目的 探讨油菜资源中吲哚硫苷降解物对肿瘤的抑制作用及对免疫功能的影响。方法 分别将两种不同提取法制备的高、低浓度的吲哚硫苷对S180小鼠ig给药，ip环磷酰胺。结果 吲哚硫苷降解物2号高浓度和吲哚硫苷降解物1号低浓度治疗组与生理盐水对照组相比有明显的抑制作用，能增加淋巴细胞转化率。结论 吲哚硫苷降解物可能是通过增强机体免疫功能来抑制移植性肿瘤生长，起到抗肿瘤的作用。
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| 关 键 词： | 油菜 吲哚硫苷降解物 S180小鼠 抗肿瘤作用 实验研究 |
| 文章编号： | 0253-2670(2002)04-0331-03 |
| 收稿时间： | 8/8/2001 12:00:00 AM |
| 修稿时间： | 2001年8月8日 |
Studies on antitumor effect of INDL-GLN in rape on mice transplanted S180 cell |
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| Wen Biling,Li Peiwu,Li Hangsen,Zhao Li,Yu Ping,Zou Junqing,Zhang Wen,Dian Xiaoxi,Yang Mei,Wang Xuefang and Wu Yu.Studies on antitumor effect of INDL-GLN in rape on mice transplanted S180 cell[J].Chinese Traditional and Herbal Drugs,2002,33(4):331-333. |
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| Authors: | Wen Biling Li Peiwu Li Hangsen Zhao Li Yu Ping Zou Junqing Zhang Wen Dian Xiaoxi Yang Mei Wang Xuefang and Wu Yu |
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| Affiliation: | Affiliated Hospital of Hubei College of TCM, Wuhan Hubei 430061, China;Oil Cropps Research Institute of Chinese Academy of Agriculture Sciences, Wuhan Hubei 430062, China;Affiliated Hospital of Hubei College of TCM, Wuhan Hubei 430061, China;Affiliated Hospital of Hubei College of TCM, Wuhan Hubei 430061, China;Affiliated Hospital of Hubei College of TCM, Wuhan Hubei 430061, China;Affiliated Hospital of Hubei College of TCM, Wuhan Hubei 430061, China;Affiliated Hospital of Hubei College of TCM, Wuhan Hubei 430061, China;Oil Cropps Research Institute of Chinese Academy of Agriculture Sciences, Wuhan Hubei 430062, China;Oil Cropps Research Institute of Chinese Academy of Agriculture Sciences, Wuhan Hubei 430062, China;Oil Cropps Research Institute of Chinese Academy of Agriculture Sciences, Wuhan Hubei 430062, China;Oil Cropps Research Institute of Chinese Academy of Agriculture Sciences, Wuhan Hubei 430062, China |
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| Abstract: | Object To study the antitumor and immunological effect of IN DL-GLN in rape on the cancerous mice transplanted S180 cell. Methods The treatment group was administrated(ig)IN DL-GLN at two doses(high and low dose),control group was administrated(ip)cyclophophamide.The mechanism of its antitumoraction was assessed by lymphocyte convertion test.Results Both high(No.2)and low (No.1)doses of INDL-GLN exhibited significant antitumor effects as compared with the control group,the lymphocyte convertion rate was increased,respectively.Conclusion IN DLO-GLN has great antitumor activity and immunostimulation,its antitumor mechanism may be due to its immunostimulation. |
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| Keywords: | S180 |
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