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[6]-Gingerol-loaded cellulose acetate electrospun fibers as a topical carrier for controlled release |
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| Authors: | Thanaporn Chantarodsakun Thammasit Vongsetskul Kulachart Jangpatarapongsa Patoomratana Tuchinda Sukanda Uamsiri Chuthamas Bamrungcharoen Supeecha Kumkate Pakorn Opaprakasit Pramuan Tangboriboonrat |
| Affiliation: | 1. Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand 2. Center for Innovation Development and Technology Transfer, Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Nakhonprathom, 73170, Thailand 3. Department of Biology, Faculty of Science, Mahidol University, Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand 4. School of Bio-Chemical Engineering and Technology, Sirindhorn International Institute of Technology (SIIT), Thammasat University, Pathum Thani, 12120, Thailand |
| Abstract: | 6]-Gingerol (6 % w/v)-loaded cellulose acetate (12 % w/v CA; MW ~ 3 × 104 g/mol) fibers (375 ± 107 nm) were prepared by electrospinning at 7.5 kV. ATR-FTIR spectra indicated that the mixture was miscible at this composition. Differential scanning calorimetry revealed that 6]-gingerol was uniformly dispersed in the CA matrix and interrupted the hydrogen bond formation among the CA chains. Controlled release study showed that ~97 % of the loaded 6]-gingerol could be released from the loaded fibers to the acetate buffer solution at 37 °C, whereas only ~74 % of it could be done from the corresponding films. About 92 % of 6]-gingerol in the fibers was dramatically released within 4 h. Release was mainly governed by a diffusion-controlled mechanism. The radical scavenging assay showed antioxidant activity of the loaded fibers. The in vitro cytotoxicity test revealed that the viability of L-929 mouse fibroblast cells to the loaded fibers was ~65 %. |
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