阿立哌唑治疗首发精神分裂症的临床观察

目的了解阿立哌唑对首发精神分裂症患者的疗效与耐受性。方法用阿立哌唑治疗56例首发精神分裂症（包括分裂样精神障碍）患者6周,采用阳性与阴性症状量表（PANSS）、副反应量表（TESS）评定疗效及不良反应。结果56例患者治疗后,临床显效率为82.14%,有效率达94.64%,治疗前后患者的PANSS减分率间差别有显著性意义（P〈0.01）,不良反应主要有轻度的锥体外系症状（EPS）、头痛、失眠、焦虑等,患者的血糖、血脂、体重治疗前后间差别均无显著性意义（P〉0.05）。结论阿立哌唑治疗首发精神分裂症患者疗效肯定,不良反应少,依从性较好。

The Effect of Aripiprazole on First-onset Schizophrenia

Objective To investigate the effect and side effects of aripiprazole on first-onset schizophrenia.Methods 56 patients with first-onset schizophrenia were treated with arripiprazole for 6 weeks,to evaluate its effect by PANSS and TESS.Results After six-week treatment,the rate of clinical effect was 82 14%,and the effective rate was 94 64%.Significant difference was found in rate of reduction between pre-treatment and post-treatment(P<0.01),and untoward effects were mainly mild EPS,headache,insomnia and anxiety etc.There was no significant difference in blood gluoose,lipid,body weight and laboratory indexes between pre-treatment and post-treatment.Conclusion The results confirm the effect of arripiprazole on patients with first-onset schizophrenia,with little untoward effects and good obedience.