| 甘蓝汁的抗诱变作用及其机理研究 |
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| 引用本文： | 莫君琴,黄幸纤.甘蓝汁的抗诱变作用及其机理研究[J].癌变．畸变．突变,1995,7(1):46-49. |
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| 作者姓名： | 莫君琴 黄幸纤 |
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| 作者单位： | 浙江杭州医科大学毒理研究室 |
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| 摘 要： | 本文通过微核试验和肝组织中谷胱甘肽－Ｓ－转移酶（ＧＳＴ）活性、还原型谷胱甘肽９ＧＳＨ）含量及细胞色素Ｐ４５０含量测定，在哺乳动物整体水平，从遗传学和生化毒理角学角度研究了甘蓝汁的抗诱变作用及其机理。结果发现，甘蓝汁对环磷酰胺（ＣＰ）诱发的小鼠骨髓多染红细胞（ＰＣＥ）微核细胞率有显著抑制作用，抑制率达４７．２％。Ｗｉｓｔａｒ大鼠饮甘蓝汁１０ｄ后，肝脏ＧＳＴ活性增加２５．０％，ＧＳＨ含量提高４７．８％
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| 关 键 词： | 甘蓝 微核试验 抗诱变作用 药理 |
STUDIES ON THE ANTIMUTAGENIC EFFECT AND ITS MECHA-NISM OFJUICE FOR B.
OLERACEA |
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| Abstract: | In the precent study the dismutagen effect of Cabbage
juice (Brassica oleraceaVar. Capitata)on cyclophosphamide(CP)induced micronuclear on PCEs
in mice bone mar-row and the effect on glutathione-s-transferase (GST)activity, glutathione
(GSH) leveland cytochrone P450 content in the liver of rats were investigated. The result
showed that theCP induced micronucleus rate was inhibited by 47.2%. The GST activity, GSH
level andP450 content were increased by 25.0%,48.0%and 37.3%,respectively,after drank the
juicefor 10 days. |
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| Keywords: | Brassica oleracea Var Capitata Micronucleus test Glutathione s transferase Glutathione Cytochrome P450 |
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