广龙昊膏药对大鼠腰椎间盘突出模型细胞因子IL-1、NO及组织胺的影响

为探讨IL-1、NO及组织胺在腰椎间盘突出中的作用及广龙昊膏药的治疗效果，将60只大鼠造模并随机分为正常组（A组）、造模组（B组）、广龙昊膏药组（C组）和奇正止痛膏组（D组），观察其神经根周围局部组织中IL-1、NO及组织胺的含量。结果显示，B组中的IL-1、NO及组织胺较A组显著升高（P〈0．01）。C组、D组较B组明显下降（P〈0．01）。表明大鼠腰椎间盘突出模型中细胞因子IL-1、NO及组织胺明显增加可能是腰椎间盘突出中的潜在始动或促进因素，而C组能显著降低神经根局部中IL-1、NO及组织胺的含量，说明广龙昊膏药作用部分是通过抑制炎性细胞因子的活性实现的。

INFLUENCE OF "GUANGLONGHAO GAO" ON IL- 1, NO AND HISTAMINE IN RAT MODELS OF LUMBAR INTERVERTEBRAL DISK HERNIA

The objective of the paper is to study the action of IL-1,NO and histamine in rat models of lumbar intervetebral disk hernia(LIDH) and the influence of "GUANGLONGHAO GAO"(GLHG,a TCD plaster) on IL-1,NO and histamine.Sixty rats were randomly divided into Group A(the normal),Group B(the modeled),Group C(treated by GLHG) and Group D(treated by "QIZHENG ZHITONG GAO"),and the levels of IL-1,NO and histamine in the local tissues around the nerve root were observed.The results showed that IL-1,NO and histamine in Group B ascended significantly compared with the ones of Group A(P < 0.01) but the ones of Group C and Group D descent significantly compared with the ones of Group B(P < 0.01),suggesting that IL-1,NO and histamine in rat LIDH models were significantly increased,which may be the latent initiating and promoting factor of LIDH;GLHG could obviously reduce the levels of IL-1,NO and histamine in the local tissues of the nerve root;the function of GLHG may be partly accomplished through inhibiting the activity of inflammatory cell factors.