2型糖尿病肾病患者血胱抑素C、尿蛋白排泄与糖化血红蛋白的关系研究

目的：观察 2 型糖尿病并发肾病患者的血清胱抑素 C（Cys-C）、尿白蛋白及糖化血红蛋白 （HbA1c） 的水平及其 3 种指标之间的相互关系.方法：选取本院 2010 年 2 月 -2011 年 4 月泌尿科住院部收治的 2 型糖尿病患者 86 例,其中并发肾病患者 47 例作为观察组,无合并肾病患者39 例作为对照组,另选取 42 例体检健康者作为空白组,患者均于空腹 12 h 后采血,收集并留取 24 h 尿,检测患者 Cys-C、24 h 尿白蛋白及 HbA1c的水平,并观察三种指标之间的相关关系.结果：三组患者血肌酐水平比较,差异无统计学意义 （P〉0.05）,而三组患者 Cys-C、24 h 尿白蛋白及HbA1c 水平比较,差异具有统计学意义 （P〈0.05） ;HbA1c 与 24 h 尿白蛋白呈正相关 （r=0.482）,Cys-C 与 24 h 尿白蛋白呈正相关 （r=0.658）,HbA1c与 Cys-C 呈正相关 （r=0.359）.结论：Cys-C、24 h 尿白蛋白及 HbA1c 的水平可作为 2 型糖尿病肾病肾功能损害早期诊断的重要指标.

Study the Relation on Serum Cystatin C,Urine Protein Cxcretion and Glyeosylated Hemoglobin in Type 2 Diabetes

Objective ：To observe the levels on serum cystatin C （Cys-C）, urinary albumin and glycosylated hemoglobin （HbAlc） in Type 2 Diabetes, and explore the correlation between the three indicators.Method ：86 cases with type 2diabetes from February 2010 toApril 2011 were selected, including47 cases with kidney disease as the observation group, 39 cases without kidney disease as a control group, and 42 healthy subjects as the blank group, to blood after 12 h fasting, and collected urine for 24 h, detect Cys-C, 24 h urinary albumin and HbAlc levels, and to observe the correlation between the three indices. Result ：The serum creatinine levels between 3 groups were not significantly different （P〉0.05）, while the Cys-C, 24 h urinary albumin and HbAlc levels were significantly different, with statistical significance （P〈0.05） ; HbAlc and 24 h urinary albumin were positively correlated （r=0.482）, Cys-C and 24 h urinary albumin were positively correlated （r=0.658）, HbAlc was positively correlated with Cys-C （ r=0.359）.Condusion ：Cys-C, 24 h urinary albumin and HbAlc levels can be used as important indicators for the early diagnosis in type 2 diabetes nephropathy patients with impaired renal function.