糖脂清对实验性2型糖尿病大鼠糖脂代谢的影响*

目的]观察糖脂清对实验性2型糖尿病大鼠糖代谢和脂代谢紊乱的影响.方法]采用Wistar大鼠喂饲高脂饲料8周后,一次性腹腔注射2%链脲佐菌素30 mg/kg的方法复制2型糖尿病动物模型.按糖脂清用药剂量为3.2,1.6,0.8 g生药/kg体质量灌胃给药,以血脂康(0.25 g/kg体质量)及二甲双胍(0.25 g/kg体质量)作为阳性对照药,给药30d后检测空腹血糖、血脂、胰岛素、糖化血红蛋白水平.结果]糖脂清能显著降低实验性2型糖尿病大鼠的空腹血糖水平,降低血脂含量,降低胰岛素,糖化血红蛋白水平,升高胰岛素敏感性,与模型组比较有显著性差异(P<0.05,P<0.01).结论]糖脂清对实验性2型糖尿病大鼠模型有降低血糖,调节血脂,改善糖脂代谢紊乱的作用.

Effect of tangzhiqing on glycolipid metabolism in rats with experimental type 2 diabetes

Objective] To observe the effects of Tangzhiqing (TZQ) on glycolipid metabolism in experimental type 2 diabetic rats.Methods] Wistar rats were fed with high fat diet for 8weeks and then were injected intraperitoneally with streptozotocin (STZ,30 mg/kg) to induce experimental type 2 diabetes.The model rats were administrated with medicine at the dose of 6,3,1.5g of crude drug/kg for 30 days, using metformin hydrochloride tablets (0.25 g/kg),Xuezhikang (0.25 g/kg) as the control.At the end,the fasting blood glucose,serum lipid,insulin,glycosylated hemoglobin were measured.Results] Compared with the model group,TZQ could obviously decrease the levels of the fasting blood glucose,serum lipid,insulin,glycosylated hemoglobin (P<0.05,P<0.01),and increase insulin-sensitivity index.Conclusion] TZQ can effectively regulate glycolipid metabolism disorder.