| 黄芪、全蝎、红花、丹参、葛根混合剂抑制自发性高血压大鼠阻力血管肥厚 |
| |
| 引用本文： | 姚洁,谢良地,王华军,许昌声.黄芪、全蝎、红花、丹参、葛根混合剂抑制自发性高血压大鼠阻力血管肥厚[J].高血压杂志,2008(4). |
| |
| 作者姓名： | 姚洁 谢良地 王华军 许昌声 |
| |
| 作者单位： | 福建省高血压研究所福建医科大学附属第一医院; |
| |
| 摘 要： | 目的观察黄芪、全蝎、红花、丹参、葛根混合剂(脑心通)对自发性高血压大鼠(SHR)阻力血管结构和血压的影响。方法选择12周龄雄性 SHR 大鼠(二级)32只,随机分成4组,脑心通大剂量组1.5 g/(kg·d)]、脑心通小剂量组0.5 g/(kg·d)]、氯沙坦组30 mg/(kg·d)]和 SHR 组(给等量蒸馏水)。另选周龄、性别相匹配的Wistar Kyoto(WKY,给等量蒸馏水)大鼠8只。各组每日灌胃给药。12周后尾袖法测定动脉血压,称质量后处死。HE 染色,计算机图像分析计算血管壁腔比,以观察各组大鼠肠系膜三级动脉的结构变化。结果 1)大、小剂量脑心通治疗后,两组 SBP 均显著低于 SHR 组脑心通大剂量:(153.6±12.2)比脑心通小剂量:(159.2±5.8)比 SHR:(178.6±12.0)mmHg,P<0.01];大剂量脑心通组 SHR 治疗后 SBP 较治疗前明显降低(153.6±12.2)比治疗前(163.6±11.8)mmHg,P<0.01],与小剂量组比较能更进一步降低血压(P<0.05)。2)与 SHR 组相比,小剂量脑心通治疗对肠系膜三级动脉血管的管壁面积/管腔...
|
| 关 键 词： | 脑心通 自发性高血压大鼠 阻力血管 高血压 |
The Effect of Naoxintong on the Resistance Vessels Hypertrophy in Spontaneously Hypertensive Rats |
| |
| YAO Jie XIE Liang-di WANG Hua-jun XU Chang-sheng Fujian Hypertension Research Institute,The First Affiliated Hospital of Fujian Medical University,Fuzhou ,China.The Effect of Naoxintong on the Resistance Vessels Hypertrophy in Spontaneously Hypertensive Rats[J].Chinese Journal of Hypertension,2008(4). |
| |
| Authors: | YAO Jie XIE Liang-di WANG Hua-jun XU Chang-sheng Fujian Hypertension Research Institute The First Affiliated Hospital of Fujian Medical University Fuzhou China |
| |
| Affiliation: | YAO Jie XIE Liang-di WANG Hua-jun XU Chang-sheng Fujian Hypertension Research Institute,The First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China |
| |
| Abstract: | |
| |
| Keywords: | Naoxintong Spontaneously hypertensive rats Resistance vessels Hypertension |
| 本文献已被 CNKI 等数据库收录！ |
|
