| 中药正肝化瘀方对肝纤维化大鼠肝组织胶原代谢的影响 |
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| 引用本文： | 吴其恺,刘丽婵,杨大国,陶艳艳,邓欣,王清兰.中药正肝化瘀方对肝纤维化大鼠肝组织胶原代谢的影响[J].山西中医学院学报,2011,12(5):4-6. |
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| 作者姓名： | 吴其恺 刘丽婵 杨大国 陶艳艳 邓欣 王清兰 |
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| 作者单位： | 1. 广东省深圳市第三人民医院中西医结合肝病科,广东深圳,518020
2. 上海中医药大学肝病研究所,上海,201203 |
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| 基金项目： | 广东省中医药管理局科研立项课题(20070240,2008276) |
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| 摘 要： | 目的:观察正肝化瘀方对肝纤维化大鼠肝组织胶原代谢的影响。方法:采用四氯化碳+高脂低蛋白饮食制备大鼠肝纤维化模型,治疗组以正肝化瘀方灌胃,正常组、模型组予以等量生理盐水灌胃,6 w后取材检测。用Jamall氏法测定各组大鼠肝组织羟脯氨酸(Hyp)含量,Western blot法检测各组大鼠肝组织α-SMA、Ⅰ型、Ⅳ型胶原蛋白的表达。结果:与模型组比较,治疗组大鼠肝组织Hyp含量及α-SMA、Ⅰ/Ⅳ型胶原蛋白表达均降低(P<0.05,P<0.01)。结论:正肝化瘀方的抗肝纤维化机制与减少肝组织胶原合成与沉积有关。
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| 关 键 词： | 正肝化瘀方 肝纤维化 胶原蛋白 |
Effects of Zhenggan Huayu Recipe on Collagen Metabolism of Hepatic Tissues of Hepatic Fibrosis Rats |
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| Wu Qikai,Liu Lichan,Yang Daguo,Tao Yanyan,Deng Xin,Wang Qinglan.Effects of Zhenggan Huayu Recipe on Collagen Metabolism of Hepatic Tissues of Hepatic Fibrosis Rats[J].Journal of Shanxi College of Traditional Chinese Medicine,2011,12(5):4-6. |
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| Authors: | Wu Qikai Liu Lichan Yang Daguo Tao Yanyan Deng Xin Wang Qinglan |
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| Affiliation: | Wu Qikai1,Liu Lichan1,Yang Daguo1,Tao Yanyan2,Deng Xin1,Wang Qinglan2(1.The Third People Hospital of Shenzhen City,Shenzhen Guangdong 518020,2.The Institute of Hepatology,Shanghai University of TCM,Shanghai 201203) |
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| Abstract: | Objective:To observe effects of Zhenggan Huayu Recipe(ZGHYR)on collagen metabolism of hepatic tissues of hepatic fibrosis rats.Methods:Hepatic fibrosis rat models were built by phenixin combined with food of high fat and low protein.All rats were divided randomly into 3 groups:normal group,model group and treatment group.Rats in treatment group were given ZGHYR decoction by intragastrically administration for six weeks,while rats in normal group and model group were administered same volume normal saline.Af... |
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| Keywords: | Zhenggan Huayu Recipe hepatic fibrosis collagen |
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