| 用RP-HPLC法考察头孢噻利与维生素C的配伍稳定性 |
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| 引用本文： | 华俊彦,叶伟红,田伟强,周越.用RP-HPLC法考察头孢噻利与维生素C的配伍稳定性[J].中国临床药理学杂志,2011,27(3). |
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| 作者姓名： | 华俊彦 叶伟红 田伟强 周越 |
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| 作者单位： | 丽水市中心医院药剂科,浙江,丽水,323000 |
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| 基金项目： | 浙江省医学会基金资助项目 |
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| 摘 要： | 目的 考察注射用硫酸头孢噻利(第4代头抱类抗生素)与维生素C注射液在5%葡萄糖注射液中的配伍稳定性.方法 用反相高效液相色谱法,测定注射用硫酸头孢噻利与维生素C配伍后两者的含量变化,观察和检测配伍液的外观及pH值的变化.结果 室温下配伍液8h内,外观、pH值及含量无明显变化.结论 注射用硫酸头孢噻利与维生素C注射液在5%葡萄糖注射液中配伍后于室温下8h内可使用.
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| 关 键 词： | 反相高效液相色谱法 硫酸头孢噻利 维生素C 配伍稳定性 |
Compatible stability of cefoselis sulsate for injection with vitamin C injection by RP-HPLC |
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| HUA Jun-yan,YE Wei-hong,TIAN Wei-qiang,ZHOU Yue.Compatible stability of cefoselis sulsate for injection with vitamin C injection by RP-HPLC[J].The Chinese Journal of Clinical Pharmacology,2011,27(3). |
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| Authors: | HUA Jun-yan YE Wei-hong TIAN Wei-qiang ZHOU Yue |
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| Affiliation: | HUA Jun-yan,YE Wei-hong,TIAN Wei-qiang,ZHOU Yue(Department of Pharmacy,Lishui Central Hospital,Lishui 323000,Zhejiang Province,China) |
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| Abstract: | Objective To study the compatible stability of cefoselis sulsate for injection and vitamin C injection in 5% grape sugar(GS) injection.Methods The content of the mixture in 5%GS injection were determined by RP-HPLC.The appearance of the solution was observed and its pH value was determined.Results There were no evident changes in appearance,pH value and the content of the mixed fluid within 8 h at room temperature.Conclusion The mixture of cefoselis sulsate for injection and vitamine C injection in 5%GS inj... |
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| Keywords: | RP-HPLC cefoselis sulsate vitamin C compatible stability |
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