Intravaginal Controlled Administration of Flurogestone Acetate: (III) Development of Rate-Control Vaginal Devices期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Intravaginal Controlled Administration of Flurogestone Acetate: (III) Development of Rate-Control Vaginal Devices

Authors:	Mohan Kabadi Yie W Chien

Affiliation:	^a Controlled Drug Delivery Research Center Rutgers University College of Pharmacy Busch Campus, Piscataway, New Jersey ^b Recipient of Synkron Graduate Research Fellowship, Morris Plains, NJ ^c Controlled Drug Delivery Research Center, College of Pharmacy, Rutgers University, Piscataway, New Jersey

Abstract:	A Rate-Control vaginal device was developed which overcomes the low bioavailability and unpredictable Q - t^1/2 type release and absorption rate profiles of flurogestone acetate delivered by the currently marketed Syncro-Mate pessary. The in vitro release and vaginal absorption profiles from the Rate-Control vaginal device were run simultaneously, a linear Q - t relationship was obtained with a significant improvement in bioavailability. A mathematical model was developed to correlate the in vitro drug release and the vaginal absorption profiles of flurogestone acetate from the vaginal devices. The design, development and the simultaneous release and absorption profiles of flurogestone acetate from this new vaginal device were outlined and discussed.

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